| An update on the role of leukotrienes in asthma. | |
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MedLine Citation:
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PMID: 19915456 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: Leukotrienes are lipid mediators involved in the pathogenesis of asthma. There is significant new information about the actions of leukotrienes in asthma and the evolving role of antileukotriene therapies. We review recent findings on regulation of leukotriene synthesis, biological function of leukotrienes in disease models, and use of leukotriene modifiers in clinical practice. RECENT FINDINGS: Our understanding of the regulation of leukotriene synthesis at a molecular level has greatly advanced. Recent evidence indicates that genetic variation in the leukotriene synthetic pathway affects the clinical response to leukotriene modifiers. The participation of leukotriene B4 in the allergic sensitization process in animal models suggests a larger role for leukotriene B4 in asthma. Preclinical and in-vitro models suggest that the cysteinyl leukotrienes are important in airway remodeling. Leukotrienes are key mediators of exercise-induced bronchoconstriction with recent studies demonstrating that leukotriene modifiers reduce the severity of exercise-induced bronchoconstriction during short-term and long-term use. SUMMARY: Leukotrienes are clearly involved in airway inflammation and certain clinical features of asthma. Evolving evidence indicates that leukotriene B4 has an important role in the development of asthma and that cysteinyl leukotrienes are key mediators of the airway remodeling process. |
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Authors:
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Teal S Hallstrand; William R Henderson |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current opinion in allergy and clinical immunology Volume: 10 ISSN: 1473-6322 ISO Abbreviation: Curr Opin Allergy Clin Immunol Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2009-12-22 Completed Date: 2010-06-09 Revised Date: 2011-07-22 |
Medline Journal Info:
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Nlm Unique ID: 100936359 Medline TA: Curr Opin Allergy Clin Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 60-6 Citation Subset: IM |
Affiliation:
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University of Washington, Seattle, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Airway Remodeling
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drug effects Animals Asthma / drug therapy, genetics, immunology*, physiopathology Disease Progression Humans Leukotriene Antagonists / therapeutic use Leukotrienes / genetics, immunology* Polymorphism, Genetic |
| Grant Support | |
ID/Acronym/Agency:
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R01 AI042989-10/AI/NIAID NIH HHS; R01 HL089215-02/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Leukotriene Antagonists; 0/Leukotrienes |
| Comments/Corrections | |
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