Document Detail


An update of mortality among chemical workers potentially exposed to the herbicide 2,4-dichlorophenoxyacetic acid and its derivatives.
MedLine Citation:
PMID:  8113924     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Four years of additional mortality follow-up through 1986 are reported for a previously studied cohort of 878 chemical workers who were potentially exposed to 2,4-dichlorophenoxyacetic acid (2,4-D) and its derivatives between 1945 and 1983. Observed mortality was compared with expected levels based on death rates of the US population and of 36,804 "unexposed" workers from the same manufacturing location. Non-Hodgkin's lymphoma (NHL) was a particular focus of the study because of a suggested association with 2,4-D exposure in some case-control studies. For the total observation period, the standardized mortality ratios for all causes and for malignant neoplasms were 92 and 91, respectively. Analyses using the internal comparison group yielded virtually identical results. The initial study had found two deaths from NHL, both of which occurred under circumstances (ie, short latency and modest exposure) which made it less plausible that they were related to 2,4-D exposure. No new deaths from NHL were observed in the extended follow-up period and mortality for this cause showed a nonstatistically significant excess (standardized mortality ratio, 196; 95% confidence interval 24 to 708) for the total observation period. Analyses by production area, and by two different measures of exposure, combined with two different approaches to account for latency, did not show patterns suggestive of a causal relationship between exposure to 2,4-D or its derivatives and any particular cause of death.
Authors:
L J Bloemen; J S Mandel; G G Bond; A F Pollock; R P Vitek; R R Cook
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of occupational medicine. : official publication of the Industrial Medical Association     Volume:  35     ISSN:  0096-1736     ISO Abbreviation:  J Occup Med     Publication Date:  1993 Dec 
Date Detail:
Created Date:  1994-03-31     Completed Date:  1994-03-31     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7502807     Medline TA:  J Occup Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1208-12     Citation Subset:  IM    
Affiliation:
Dow Benelux NV, Terneuzen, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
2,4-Dichlorophenoxyacetic Acid / adverse effects*,  analogs & derivatives*
Cause of Death*
Chemical Industry*
Cohort Studies
Follow-Up Studies
Humans
Lymphoma, Non-Hodgkin / chemically induced,  mortality
Neoplasms / chemically induced*,  mortality
Occupational Diseases / chemically induced*,  mortality
Occupational Exposure / adverse effects*
Risk Factors
United States / epidemiology
Chemical
Reg. No./Substance:
94-75-7/2,4-Dichlorophenoxyacetic Acid
Comments/Corrections
Comment In:
J Occup Environ Med. 1995 Feb;37(2):126-7   [PMID:  7655952 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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