Document Detail


An update on immunotherapy for food allergy.
MedLine Citation:
PMID:  20856110     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: Recent investigation has resulted in significant advances toward definitive therapeutic options for food allergy. In this review, we will explore novel immunotherapeutic interventions for the active treatment of food allergy.
RECENT FINDINGS: Because the injection route for allergen immunotherapy to foods has been associated with an unacceptable risk of severe anaphylactic reactions, use of mucosally targeted therapeutic strategies is of significant interest for food allergy. Allergen-specific immunotherapeutic approaches such as oral, sublingual, epicutaneous, and peptide immunotherapy have demonstrated efficacy in increasing threshold dose and inducing immunologic changes associated with both desensitization and oral tolerance in animal and human trials. More global immunomodulatory strategies, such as Traditional Chinese Medicine and anti-IgE therapy have been shown to effectively target the allergic response, and clinical trials are ongoing to determine the efficacy and safety in human food allergy.
SUMMARY: The advent of therapies that target the mucosal immune response to promote oral tolerance have shown great promise in the treatment of food hypersensitivity. However, there is still significant risk of adverse reactions associated with these therapeutic strategies and further study is needed to carefully advance these therapeutic modalities toward general clinical implementation.
Authors:
Amy M Scurlock; Stacie M Jones
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in allergy and clinical immunology     Volume:  10     ISSN:  1473-6322     ISO Abbreviation:  Curr Opin Allergy Clin Immunol     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-10-29     Completed Date:  2011-05-24     Revised Date:  2014-09-05    
Medline Journal Info:
Nlm Unique ID:  100936359     Medline TA:  Curr Opin Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  587-93     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Allergens / immunology,  therapeutic use*
Animals
Antibodies, Monoclonal / therapeutic use*
Clinical Protocols
Clinical Trials as Topic
Food / adverse effects
Food Hypersensitivity / drug therapy*,  immunology
Humans
Immune Tolerance / drug effects
Immunity, Mucosal / drug effects
Medicine, Chinese Traditional
Risk Assessment
Grant Support
ID/Acronym/Agency:
K08 AI077932/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Allergens; 0/Antibodies, Monoclonal
Comments/Corrections

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