| An update on emerging drugs for asthma. | |
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MedLine Citation:
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PMID: 22292562 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Introduction: It is recognized that airway inflammation is key to asthma pathogenesis. Biopharmaceutical approaches have identified new therapies that target key cells and mediators that drive the inflammatory responses in the asthmatic lung. Such an approach resulted in the development of biologics including IL-4, IL-5 and IL-13. However, clinical trials with these biologics in patients with asthma were for the most part disappointing even though they proved to be highly effective in animal models of asthma. Areas covered: This review based on English-language original articles in PubMed or MedLine published in the last 5 years will update the current status, therapeutic potential and potential problems of recent drug developments in asthma therapy. Expert opinion: It is becoming apparent that significant clinical effects with anti-cytokine-based therapies are more likely in carefully selected patient populations that take asthma phenotypes into account. It might also be more clinically effective if more than one cytokine and/or chemokine were to be targeted rather than a single mediator. |
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Authors:
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Garry M Walsh |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-31 |
Journal Detail:
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Title: Expert opinion on emerging drugs Volume: - ISSN: 1744-7623 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-2-1 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101135662 Medline TA: Expert Opin Emerg Drugs Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Section of Immunology & Infection Division of Applied Medicine, School of Medicine & Dentistry Institute of Medical Sciences, University of Aberdeen, Foresterhill , Aberdeen AB25 2ZD, Scotland , UK +44 0 1224 437354 ; +44 0 1224 437348 ; g.m.walsh@abdn.ac.uk. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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