Document Detail

An update on the dietary ligands of the AhR.
MedLine Citation:
PMID:  18950284     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Halogenated aromatic hydrocarbons including dioxins and non-halogenated polycyclic aromatic hydrocarbons are ligands of an aryl hydrocarbon receptor (AhR) and stimulate its transformation. Exposure to these environmental contaminants occurs mainly through diet. Recent articles demonstrated that certain food factors regulate the AhR transformation and expression of downstream drug-metabolizing enzymes. OBJECTIVE: To explain the actions of these food factors on the AhR transformation, as the mechanisms underlying are not fully understood. METHODS: This review introduces recent articles that have demonstrated the molecular mechanisms by which food factors regulate the AhR transformation and downstream drug-metabolizing enzymes. RESULTS/CONCLUSION: The role of classical ligands including dioxins as agonists of the receptor is well documented. As to the food factors, they act as antagonists because they basically suppress the AhR transformation by different mechanisms. Moreover, the fate and metabolism of food factors are important to understand their mechanisms.
Hitoshi Ashida; Shin Nishiumi; Itsuko Fukuda
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Expert opinion on drug metabolism & toxicology     Volume:  4     ISSN:  1742-5255     ISO Abbreviation:  Expert Opin Drug Metab Toxicol     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-10-27     Completed Date:  2009-01-30     Revised Date:  2009-11-16    
Medline Journal Info:
Nlm Unique ID:  101228422     Medline TA:  Expert Opin Drug Metab Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1429-47     Citation Subset:  IM    
Kobe University, Graduate School of Agricultural Science, Department of Agrobioscience, 1-1 Rokkodai-cho, Kobe 657-8501, Nada-ku, Japan.
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MeSH Terms
Carotenoids / metabolism
Curcumin / metabolism
Enzymes / metabolism
Flavonoids / metabolism
Food Analysis
Pharmaceutical Preparations / metabolism
Receptors, Aryl Hydrocarbon / genetics,  metabolism*
Reg. No./Substance:
0/Enzymes; 0/Flavonoids; 0/Pharmaceutical Preparations; 0/Receptors, Aryl Hydrocarbon; 36-88-4/Carotenoids; 458-37-7/Curcumin

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