Document Detail


An update on cohesin function as a 'molecular glue' on chromosomes and spindles.
MedLine Citation:
PMID:  20436296     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
One of the critical events in mitosis is proper sister chromatid cohesion, which is mediated by a protein complex called cohesin. The cohesin complex is best known for its role in tethering the sister DNA molecules. This review summarizes recent progress in understanding the functions of cohesin, and of its major subunits, SMC1, SMC3, Scc1 and Scc3. It is now clear that cohesin also plays crucial roles in controlling transcription and gene expression, DNA damage repair and spindle pole formation; functions that are beyond the traditional view of cohesin as a 'molecular glue' that holds sister chromosomes together.
Authors:
Richard W Wong
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-05-18
Journal Detail:
Title:  Cell cycle (Georgetown, Tex.)     Volume:  9     ISSN:  1551-4005     ISO Abbreviation:  Cell Cycle     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-31     Completed Date:  2010-09-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137841     Medline TA:  Cell Cycle     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1754-8     Citation Subset:  IM    
Affiliation:
Frontier Science Organization and Cancer Research Institute, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa, Japan. rwong@staff.kanazawa-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Cell Cycle Proteins / chemistry,  metabolism,  physiology*
Centrosome / metabolism
Chromosomal Proteins, Non-Histone / chemistry,  metabolism,  physiology*
Chromosomes / metabolism*
Chromosomes, Human / metabolism
Humans
Mitotic Spindle Apparatus / metabolism*
Nuclear Proteins / metabolism
Phosphoproteins / metabolism
Proteochondroitin Sulfates / metabolism
Chemical
Reg. No./Substance:
0/Cell Cycle Proteins; 0/Chromosomal Proteins, Non-Histone; 0/Nuclear Proteins; 0/Phosphoproteins; 0/Proteochondroitin Sulfates; 0/RAD21 protein, human; 0/SMC3 protein, human; 0/cohesins; 0/structural maintenance of chromosome protein 1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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