Document Detail

An update on antenatal screening for Down's syndrome and specific implications for assisted reproduction pregnancies.
MedLine Citation:
PMID:  16672245     Owner:  NLM     Status:  MEDLINE    
Since the introduction of antenatal serum screening for Down's syndrome (DS) more than two decades ago, several screening approaches have been utilized in routine clinical practice. The current DS screening strategies involve mid-trimester serum biochemistry tests, first trimester tests combining sonographic markers and serum biochemistry and integration of first and second trimester markers. In this review, we evaluate the performance of DS screening strategies according to the Serum, Urine and Ultrasound Screening Study (SURUSS), the First and Second Trimester Evaluation of Risks (FASTER) Trial and the Serum Biochemistry and Fetal Nuchal Translucency Screening (BUN) Study. We also evaluate the performance of first trimester screening in studies and meta-analyses by other groups. Specific issues related to assisted reproduction technology (ART) pregnancies are also addressed in this review.
Boaz Weisz; Charles H Rodeck
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Publication Detail:
Type:  Journal Article; Review     Date:  2006-05-03
Journal Detail:
Title:  Human reproduction update     Volume:  12     ISSN:  1355-4786     ISO Abbreviation:  Hum. Reprod. Update     Publication Date:    2006 Sep-Oct
Date Detail:
Created Date:  2006-08-14     Completed Date:  2006-11-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9507614     Medline TA:  Hum Reprod Update     Country:  England    
Other Details:
Languages:  eng     Pagination:  513-8     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, Sheba Medical Center, Tel-Hashomer, Israel.
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MeSH Terms
Biological Markers
Down Syndrome / diagnosis*
Maternal Age
Pregnancy Trimester, First
Pregnancy Trimester, Second
Pregnancy, Multiple
Prenatal Diagnosis / methods*,  standards
Reproductive Techniques, Assisted*
Risk Assessment
Sensitivity and Specificity
Reg. No./Substance:
0/Biological Markers

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