Document Detail


An unusual reciprocal X-autosome translocation in an infertile azoospermic man.
MedLine Citation:
PMID:  17383648     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To analyze an unusual reciprocal X-autosome translocation found in an infertile man with azoospermia. DESIGN: Case report with a review of scientific literature. SETTING: Male infertility clinic, Kobe University Hospital. PATIENT(S): Infertile man with azoospermia but otherwise apparently healthy. INTERVENTION(S): Peripheral blood lymphocytes were obtained for karyotyping, and metaphases were studied by fluorescence in situ hybridization procedure. MAIN OUTCOME MEASURE(S): Seminal analysis, hormone levels, volume of testis, and pathologic analysis of testis were performed. RESULT(S): The semen analysis revealed azoospermia. The lymphocytic karyotype showed a man with X-autosome translocations. Histopathologic examination of the sample showed maturation arrest. CONCLUSION(S): This is the first clinical report of azoospermia with reciprocal X-autosome 11 translocations. This translocation may be a direct genetic risk factor for maturation arrest.
Authors:
Tomomoto Ishikawa; Yutaka Kondo; Kohei Yamaguchi; Takeshi Oba; Yuichi Sakamoto; Atsushi Takenaka; Masato Fujisawa
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Publication Detail:
Type:  Journal Article     Date:  2007-03-26
Journal Detail:
Title:  Fertility and sterility     Volume:  88     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-09-11     Completed Date:  2007-09-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  705.e15-7     Citation Subset:  IM    
Affiliation:
Division of Urology, Department of Organs Therapeutics, Faculty of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan. iskwtmmt@med.kobe-u.ac.jp <iskwtmmt@med.kobe-u.ac.jp>
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MeSH Terms
Descriptor/Qualifier:
Azoospermia / genetics*
Chromosomes, Human, X*
Humans
Infertility, Male / genetics*
Male
Middle Aged
Protein Biosynthesis*
Sex Chromosome Aberrations*

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