Document Detail

An unusual presentation of cortical venous thrombosis and its association with typical antipsychotics.
MedLine Citation:
PMID:  22679157     Owner:  NLM     Status:  MEDLINE    
A 41-year-old patient with schizophrenia was admitted to hospital following episodes of unexplained collapse attacks and on and off episodes of frontal headaches for 3 months. After three such episodes of loss of consciousness in 2 weeks duration and subsequent spontaneous recovery, his evaluation which included MRI scan of head revealed extensive cortical venous thrombosis. He was on zuclopenthixol (thioxanthene group) for several months for schizophrenia and was under regular psychiatric evaluation. He was treated for simple lower respiratory infection a week prior to admission. Other causes for any clotting disorders including vasculitic and thrombophilic screen were negative. There was no evidence of focal neurology on examination. Systemic examination was otherwise unremarkable. He was treated initially with unfractionated heparin and subsequently changed to warfarin with target international normalised ratio between two and three for at least 6 months and psychiatrist was advised to stop zuclopenthixol.
Sreeman Narayan Andole
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2011-10-04
Journal Detail:
Title:  BMJ case reports     Volume:  2011     ISSN:  1757-790X     ISO Abbreviation:  BMJ Case Rep     Publication Date:  2011  
Date Detail:
Created Date:  2012-06-08     Completed Date:  2013-05-24     Revised Date:  2013-10-17    
Medline Journal Info:
Nlm Unique ID:  101526291     Medline TA:  BMJ Case Rep     Country:  England    
Other Details:
Languages:  eng     Pagination:  -     Citation Subset:  IM    
Department of Neurosciences, Barking Havering and Redbridge University Hospitals NHS Trust, Romford, UK.
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MeSH Terms
Anticoagulants / therapeutic use
Antipsychotic Agents / adverse effects*
Cerebral Veins*
Clopenthixol / adverse effects*
Heparin / therapeutic use
Magnetic Resonance Imaging
Schizophrenia / drug therapy*
Venous Thrombosis / chemically induced*,  diagnosis,  drug therapy
Warfarin / therapeutic use
Reg. No./Substance:
0/Anticoagulants; 0/Antipsychotic Agents; 81-81-2/Warfarin; 9005-49-6/Heparin; 982-24-1/Clopenthixol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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