Document Detail

An unusual presentation of classic polyarteritis nodosa in a child.
MedLine Citation:
PMID:  15809832     Owner:  NLM     Status:  MEDLINE    
Classic polyarteritis nodosa (c-PAN) is a rare disease in adults and extremely rare in children. We report a 3-year-old girl with c-PAN who presented with disturbances of consciousness and hypertension. Cranial tomography showed a subarachnoid hemorrhage. Subsequent magnetic resonance imaging and magnetic resonance angiography demonstrated subarachnoid hemorrhage and acute ischemic lesions. Renal angiography revealed bilateral multiple aneurysms. Due to her constitutional symptoms and hypertension and radiological findings she was diagnosed as having c-PAN. She was successfully treated with hydralazine followed by angiotensin-converting enzyme inhibitor, calcium channel blocker, intravenous pulse methylprednisolone, and subsequently oral prednisolone and oral cyclophosphamide. To our knowledge this is the youngest patient with c-PAN presenting with subarachnoid hemorrhage. Malign hypertension at this young age deserves a meticulous investigation of the vascular origin. Furthermore, treatment with pulse methyl prednisolone followed by oral prednisolone and oral cyclophosphamide is a successful modality of treatment in such a life-threatening presentation of c-PAN in childhood.
Rezan Topaloglu; Mediha Kazik; Isil Saatci; Mukaddes Kalyoncu; Barbaros E Cil; Nejat Akalan
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2005-04-05
Journal Detail:
Title:  Pediatric nephrology (Berlin, Germany)     Volume:  20     ISSN:  0931-041X     ISO Abbreviation:  Pediatr. Nephrol.     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-06-16     Completed Date:  2005-10-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8708728     Medline TA:  Pediatr Nephrol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1011-5     Citation Subset:  IM    
Department of Pediatrics, Faculty of Medicine, Hacettepe University, 06100 Ankara, Turkey.
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MeSH Terms
Acute Disease
Aneurysm / etiology*
Brain / pathology,  radiography
Brain Ischemia / etiology*
Cerebral Angiography
Child, Preschool
Hypertension / etiology*
Intracranial Aneurysm / etiology*
Magnetic Resonance Imaging
Polyarteritis Nodosa / complications*,  diagnosis,  drug therapy
Renal Artery*
Subarachnoid Hemorrhage / etiology*
Tomography, X-Ray Computed

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