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An unusual presentation of anti-Hu-associated paraneoplastic limbic encephalitis.
MedLine Citation:
PMID:  22320677     Owner:  NLM     Status:  Publisher    
Paraneoplastic limbic encephalitis is a rare disorder characterized by personality changes, seizures, memory loss, and psychiatric symptoms often associated with antineuronal antibodies. It is well described in the adult literature but is still underreported in the pediatric literature. Symptoms are usually multifocal and subacute in presentation, occurring over days to weeks; however, in rare cases, symptom onset can be more gradual. We report the case of a 9-year-old male with anti-Hu-associated paraneoplastic limbic encephalitis that presented as episodic ataxia and behavioral changes evolving to intractable epilepsy and worsening behavioral changes over the course of a year. This case highlights the importance of considering a paraneoplastic disorder in the differential diagnosis for unexplained multifocal neurological symptoms of subacute or chronic onset as earlier detection and treatment may result in an improved outcome.
Jennifer E Langer; M Beatriz S Lopes; Nathan B Fountain; Michael R Pranzatelli; Elizabeth A Thiele; Robert S Rust; Howard P Goodkin
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-9
Journal Detail:
Title:  Developmental medicine and child neurology     Volume:  -     ISSN:  1469-8749     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0006761     Medline TA:  Dev Med Child Neurol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© The Authors. Developmental Medicine & Child Neurology © 2012 Mac Keith Press.
Department of Neurology, University of Virginia Health System, Charlottesville, VA Department of Pathology, University of Virginia Health System, Charlottesville, VA Department of Neurology, Southern Illinois University School of Medicine, Springfield, IL Department of Neurology, Massachusetts General Hospital, Boston, MA Department of Pediatrics, University of Virginia Health System, Charlottesville, VA, USA.
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