| An unusual presentation of anti-Hu-associated paraneoplastic limbic encephalitis. | |
| | |
MedLine Citation:
|
PMID: 22320677 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Paraneoplastic limbic encephalitis is a rare disorder characterized by personality changes, seizures, memory loss, and psychiatric symptoms often associated with antineuronal antibodies. It is well described in the adult literature but is still underreported in the pediatric literature. Symptoms are usually multifocal and subacute in presentation, occurring over days to weeks; however, in rare cases, symptom onset can be more gradual. We report the case of a 9-year-old male with anti-Hu-associated paraneoplastic limbic encephalitis that presented as episodic ataxia and behavioral changes evolving to intractable epilepsy and worsening behavioral changes over the course of a year. This case highlights the importance of considering a paraneoplastic disorder in the differential diagnosis for unexplained multifocal neurological symptoms of subacute or chronic onset as earlier detection and treatment may result in an improved outcome. |
| | |
Authors:
|
Jennifer E Langer; M Beatriz S Lopes; Nathan B Fountain; Michael R Pranzatelli; Elizabeth A Thiele; Robert S Rust; Howard P Goodkin |
Related Documents
:
|
21489367 - Calcinosis cutis: critical review. 8346117 - Congenital platelike osteoma cutis: case report and review of the literature. 2786837 - Histiocytosis x and lymphoid follicular hyperplasia of the thymus in myasthenia gravis. 12195007 - Endometrial cyst of the liver: a case report and review of the literature. 16124167 - Increase in the incidence of peritoneal collagen balls over a 10-year period. 1295657 - Subcapsular hematoma of spleen--a complication following extracorporeal shock wave lith... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-2-9 |
Journal Detail:
|
Title: Developmental medicine and child neurology Volume: - ISSN: 1469-8749 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
|
Created Date: 2012-2-10 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0006761 Medline TA: Dev Med Child Neurol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© The Authors. Developmental Medicine & Child Neurology © 2012 Mac Keith Press. |
Affiliation:
|
Department of Neurology, University of Virginia Health System, Charlottesville, VA Department of Pathology, University of Virginia Health System, Charlottesville, VA Department of Neurology, Southern Illinois University School of Medicine, Springfield, IL Department of Neurology, Massachusetts General Hospital, Boston, MA Department of Pediatrics, University of Virginia Health System, Charlottesville, VA, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Inhibition of FAK prevents blister formation in the neonatal mouse model of pemphigus vulgaris.
Next Document: Tumor-suppressive microRNAs silenced by tumor-specific DNA hypermethylation in cancer cells.