Document Detail

An unusual presentation of Helicobacter pylori infection: so-called "Russell body gastritis".
MedLine Citation:
PMID:  15744498     Owner:  NLM     Status:  MEDLINE    
Helicobacter pylori (H. pylori) is a "slow" bacterial pathogen, which induces several gastroduodenal diseases. Varying degrees of inflammation can be present in the gastric mucosa of patients infected with H. pylori. The case presented here is a male patient suffering from dyspepsia and nausea. His upper gastrointestinal endoscopy revealed pan gastritis. Histological examination of multiple gastric biopsies taken from the body and antrum showed a rare morphological expression of H. pylori gastritis characterized by diffuse plasma cell infiltration with extensive Russell body formation. Diffuse infiltration of plasma cells with Russell bodies in gastric mucosa can cause difficulties in differentiation from neoplastic processes. However, immunohistochemically, the infiltrating cells in the gastric mucosa stained negatively with cytokeratins while they expressed both kappa and lambda light chains showing their polyclonal nature. The presence of diffuse plasma cells with Russell bodies in the gastric mucosa may represent a different presentation of H. pylori gastritis. There are only two case reports of similar presentation and both have been called "Russell body gastritis".
Arzu Ensari; Berna Savas; Aylin Okcu Heper; Isinsu Kuzu; Ramazan Idilman
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2005-03-03
Journal Detail:
Title:  Virchows Archiv : an international journal of pathology     Volume:  446     ISSN:  0945-6317     ISO Abbreviation:  Virchows Arch.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-05-02     Completed Date:  2005-06-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9423843     Medline TA:  Virchows Arch     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  463-6     Citation Subset:  IM    
Department of Pathology, Medical School, Ankara University , Ankara, Turkey.
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MeSH Terms
Biological Markers / metabolism
Gastric Mucosa / metabolism,  microbiology,  pathology*
Gastritis / metabolism,  microbiology,  pathology*
Helicobacter Infections / metabolism,  pathology*
Helicobacter pylori* / isolation & purification,  physiology
Immunoenzyme Techniques
Immunoglobulin Heavy Chains / analysis
Immunoglobulin Light Chains / analysis
Inclusion Bodies / metabolism,  pathology
Keratins / metabolism
Plasma Cells / metabolism,  pathology
Reg. No./Substance:
0/Biological Markers; 0/Immunoglobulin Heavy Chains; 0/Immunoglobulin Light Chains; 68238-35-7/Keratins

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