| An unusual phenotypic and genotypic expression in F2 generation following one stage zidovudine exposure during pregnancy and lactation- an experiment in mice. | |
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MedLine Citation:
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PMID: 22293411 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Zidovudine (3'-Azido-2', 3'-dideoxythymidine, AZT, ZDV) is routinely used as one of the component of antiretroviral therapy to prevent transmission of the HIV infection from mother to child. The drug, when given during pregnancy can give rise to myriad toxicities as reported in previous studies on human, animal and in-vitro experiments. The present study was an attempt to explore the Zidovudine teratogenesis in F1 and F2 generation of mice following initial maternal exposure to Zidovudine during pregnancy, through delivery and lactation. The F1 generation actually would have got the exposure during embryonic development and infant stages. Pregnant Swiss mice were treated orally with ZDV 50 mg/kg/day or distilled water (control), from day eighth of gestation, through delivery and continued for first ten days of lactation. The F1 generation litters were raised and mated to produce F2 generation mice. An interesting phenotype of "healthy" and "sick" was noted in F2 generation but not in the F1 generation. In F2 generation 35% died on different postnatal day during 120 days of follow up period. Chromosomal study from bone marrow of F1 and F2 showed various chromosomal aberrations. Lipodystrophy and hepatotoxicity was observed in "sick" mice. The study generated a hypothesis of recessive mutation and concludes that Zidovudine is a transplacental genotoxic agent. The result of present study therefore suggests the need to study the effect of zidovudine in human subjects for a longer period of time to rule out similar genotoxic effect. |
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Authors:
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Chongtham Rajlakshmi; Jagat Kumar Roy; Amit Kumar Rai; Asima Bhattacharyya; Bajarang Lal Pandey |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of toxicological sciences Volume: 37 ISSN: 1880-3989 ISO Abbreviation: J Toxicol Sci Publication Date: 2012 |
Date Detail:
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Created Date: 2012-02-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7805798 Medline TA: J Toxicol Sci Country: Japan |
Other Details:
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Languages: eng Pagination: 51-61 Citation Subset: IM |
Affiliation:
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Assistant Professor, Department of Anatomy, Regional Institute of Medical Sciences, Imphal, Manipur (India) Formerly, Research Scholar, Department of Anatomy, Institute of Medical Sciences, Banaras Hindu University, India. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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