Document Detail


An unusual patient with kidney stones composed of 1-methyluric acid.
MedLine Citation:
PMID:  16397778     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An unusual case with kidney stones composed mainly of 1-methyluric acid is described. The patient, a Caucasian male of Celtic descent, reportedly drank at least eight cups of coffee per day and had a long history of rheumatoid arthritis, gouty attacks and renal colics--the latter attributed to nephrocalcinosis and analgesic nephropathy. He was treated with allopurinol. At 54 years, a bilateral nephrolithotomy was performed. Stone samples were analysed by thermogravimetry and infrared spectroscopy and reported to be 12-25% calcium oxalate, the remainder being organic uric acid-like material. Analysis of the extracts by HPLC confirmed that the organic material contained 67% of 1-methyluric acid and 33% of uric acid. Possible mechanisms leading to the precipitation of 1-methyluric acid from urine are discussed. We conclude that the high caffeine intake resulted in extremely elevated urinary concentrations of 1-methyluric acid favouring the formation of 1-methyluric acid stones.
Authors:
Phillip M Davies; Lynette D Fairbanks; Krzysztof Safranow; Michael R Bending; H Anne Simmonds
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2006-01-06
Journal Detail:
Title:  Urological research     Volume:  34     ISSN:  0300-5623     ISO Abbreviation:  Urol. Res.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-02-10     Completed Date:  2007-10-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0364311     Medline TA:  Urol Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  58-60     Citation Subset:  IM    
Affiliation:
Purine Research Unit, 5th Floor Thomas Guy House, Guy's Hospital, SE1 9RT, London Bridge, UK.
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MeSH Terms
Descriptor/Qualifier:
Adult
Caffeine / pharmacokinetics
Central Nervous System Stimulants / pharmacokinetics
Coffee
Humans
Kidney Calculi / complications*,  urine*
Kidney Failure, Chronic / etiology*,  therapy
Male
Peritoneal Dialysis, Continuous Ambulatory
Uric Acid / analogs & derivatives*,  metabolism,  urine
Chemical
Reg. No./Substance:
0/Central Nervous System Stimulants; 0/Coffee; 58-08-2/Caffeine; 69-93-2/Uric Acid; 708-79-2/1-methyluric acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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