Document Detail

An unusual patient with hypothyroidism, tophaceous gout, and marked joint destruction.
MedLine Citation:
PMID:  18600513     Owner:  NLM     Status:  MEDLINE    
This report describes a 75-year-old Caucasian man with extensive urate deposits and severe gouty arthropathy that confined him to a wheelchair. Since age 50, he suffered multiple acute gout flares and progressive deformities in his hands, feet, knees, and elbows (tophi). Serum creatinine was 1.4 mg/dL and serum urate 9.4 mg/dL. Conditions known to increase uric acid production (psoriasis, chronic bronchitis) and to decrease uric acid excretion (hypothyroidism, metabolic syndrome, and nephroangiosclerosis) may operate in a single patient, illustrating the dramatic clinical course of untreated gout.
F Montoya; R J Torres; J M Fraile; J G Puig
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Nucleosides, nucleotides & nucleic acids     Volume:  27     ISSN:  1532-2335     ISO Abbreviation:  Nucleosides Nucleotides Nucleic Acids     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-07-07     Completed Date:  2008-10-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100892832     Medline TA:  Nucleosides Nucleotides Nucleic Acids     Country:  United States    
Other Details:
Languages:  eng     Pagination:  604-7     Citation Subset:  IM    
Divisions of Internal Medicine, La Paz University Hospital, Madrid, Spain.
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MeSH Terms
Gout / complications*,  drug therapy,  metabolism,  pathology*
Hypothyroidism / complications*,  drug therapy,  metabolism,  pathology*
Joints / pathology*
Uric Acid / metabolism
Reg. No./Substance:
69-93-2/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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