Document Detail

An unusual etiology of viral hepatitis in three renal transplant recipients with normal graft function.
MedLine Citation:
PMID:  14726976     Owner:  NLM     Status:  MEDLINE    
Liver impairment in renal transplant recipients is not a common complication and is associated, in most cases, with viral infections (HBV, HCV, HVD, HGV) or drug hepatotoxicity (Cyclosporin, Azathioprine, statins). Cytomegalovirus (CMV) infection is common, with 50 to 80% of the adult population being seropositive for CMV antibodies. In immunocompetent individuals, primary infection is usually asymptomatic or associated with minor illness. CMV remains latent after primary infection. In immunocompromised patients, as in renal transplant recipients or transplant recipients of other solid organ or bone marrow, the virus can cause serious disease. This could be the result of newly acquired infection or reactivation of the latent virus. One of the organs involved in CMV disease is the liver. The subjects of this report are renal transplant recipients with liver impairment due to CMV induced acute hepatitis.
Camelia Ionescu; Gener Ismail; Ileana Constantinescu; Monica Hortopan; Olguta Iliescu; Mihaela Rosu; Mihai Voiculescu
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Romanian journal of gastroenterology     Volume:  12     ISSN:  1221-4167     ISO Abbreviation:  Rom J Gastroenterol     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2004-01-16     Completed Date:  2004-02-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9315667     Medline TA:  Rom J Gastroenterol     Country:  Romania    
Other Details:
Languages:  eng     Pagination:  303-7     Citation Subset:  IM    
Department of Internal Medicine - Nephrology, Fundeni Institute, Bucharest, Romania.
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MeSH Terms
Cytomegalovirus Infections / diagnosis*
Hepatitis, Viral, Human / diagnosis*,  virology
Immunocompromised Host
Kidney Transplantation*
Middle Aged

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