| An unusual dysplasia-malformation-cancer syndrome in two patients. | |
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MedLine Citation:
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PMID: 677167 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report two patients with a similar syndrome of gross malformation of a lower limb and contiguous structures due to involvement with dysplastic, teratomatous tissue. This dysplasia seems to have arisen in a paramedian position in the embryonic hindquarter at the time of lower limb-bud differentiation. Malignant degeneration at 5--7 months led to metastases and death in both cases around 1 year of age. The behavior of the dysplastic/oncoplastic tissue suggests a 2-"mutational" causal model. This is an apparently previously undescribed formal genesis syndrome. |
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Authors:
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M V Durkin-Stamm; E F Gilbert; D J Ganick; J M Opitz |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of medical genetics Volume: 1 ISSN: 0148-7299 ISO Abbreviation: Am. J. Med. Genet. Publication Date: 1978 |
Date Detail:
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Created Date: 1978-09-15 Completed Date: 1978-09-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7708900 Medline TA: Am J Med Genet Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 279-89 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Female Humans Infant, Newborn Leg / abnormalities* Male Mutation Syndrome Teratoma / complications, genetics* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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