Document Detail

An unusual case of prolonged tinnitus following low-dose amitriptyline.
MedLine Citation:
PMID:  18308819     Owner:  NLM     Status:  MEDLINE    
We report on a case of unilateral tinnitus after a short course of low-dose amitriptyline for neuralgic foot pain. This has been described in the literature previously at much higher doses and is associated with prolonged administration; we present our case with a review of the current literature in-order to raise awareness of this possible complication of anti-depressant therapy. We also propose a novel hypothesis for the pharmacological basis of amitriptyline-induced tinnitus.
D Mendis; M Johnston
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2008-02-28
Journal Detail:
Title:  Journal of psychopharmacology (Oxford, England)     Volume:  22     ISSN:  0269-8811     ISO Abbreviation:  J. Psychopharmacol. (Oxford)     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-08-14     Completed Date:  2008-12-16     Revised Date:  2010-08-04    
Medline Journal Info:
Nlm Unique ID:  8907828     Medline TA:  J Psychopharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  574-5     Citation Subset:  IM    
Department of ENT Surgery, Queen's Hospital, Burton-on-Trent, UK.
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MeSH Terms
Amitriptyline / administration & dosage,  adverse effects*
Antidepressive Agents, Tricyclic / administration & dosage,  adverse effects*
Dose-Response Relationship, Drug
Foot Diseases / drug therapy
Neuralgia / drug therapy
Tinnitus / chemically induced*
Reg. No./Substance:
0/Antidepressive Agents, Tricyclic; 50-48-6/Amitriptyline
Comment In:
J Psychopharmacol. 2010 Aug;24(8):1273-5   [PMID:  19825900 ]

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