| An unusual case of capecitabine hyperpigmentation: Is hyperpigmentation a part of hand-foot syndrome or a separate entity? | |
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MedLine Citation:
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PMID: 21206630 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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A 59-year-old man with adenocarcinoma of stomach was prescribed capecitabine as adjuvant chemotherapy. After two cycles of therapy, patient developed hyperpigmentation on hands and feet. Examination revealed a peculiar distribution of hyperpigmentation on hands and feet and in addition, hyperpigmented spots on the dorsum of tongue. Although hand-foot syndrome (HFS) to capecitabine solely manifesting as palmoplantar hyperpigmentation has been described earlier, this is probably the first instance wherein oral pigmentation has also been found in association. In addition, this finding lends support to the growing argument of hyperpigmentation being a separate entity: different from HFS, both therefore being separate adverse effects of the same drug. |
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Authors:
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Biju Vasudevan |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Indian journal of pharmacology Volume: 42 ISSN: 1998-3751 ISO Abbreviation: Indian J Pharmacol Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2011-01-05 Completed Date: 2011-07-14 Revised Date: 2011-07-20 |
Medline Journal Info:
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Nlm Unique ID: 7902477 Medline TA: Indian J Pharmacol Country: India |
Other Details:
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Languages: eng Pagination: 326-8 Citation Subset: - |
Affiliation:
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Department of Dermatology, MH Shillong, Shillong, Meghalaya - 793 001, India. |
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