Document Detail

An unusual case of acute psychosis in an adolescent.
MedLine Citation:
PMID:  23967726     Owner:  NLM     Status:  MEDLINE    
Anti-N-methyl-D-aspartate receptor (NMDA-R) encephalitis is a severe form of encephalitis that has been identified within the context of acute neuropsychiatric manifestations. We report the case of an 18-year-old adolescent referred for a first episode of acute psychosis. The clinical picture rapidly deteriorated to a state of catatonia, decreased consciousness and autonomic instability. Detection of highly positive anti-NMDA-R antibodies confirmed the diagnosis of anti-NMDA-R encephalitis. Immunosuppressive treatment and repeated plasma exchange resulted in slow recovery. The literature on diagnosis and treatment of this specific type of encephalitis is reviewed.
L Verfaillie; V Bissay; N Vanderbruggen; E Van Eetvelde; P M Honoré; H Spapen
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Acta clinica Belgica     Volume:  68     ISSN:  1784-3286     ISO Abbreviation:  Acta Clin Belg     Publication Date:    2013 Mar-Apr
Date Detail:
Created Date:  2013-08-23     Completed Date:  2013-09-19     Revised Date:  2014-03-18    
Medline Journal Info:
Nlm Unique ID:  0370306     Medline TA:  Acta Clin Belg     Country:  Belgium    
Other Details:
Languages:  eng     Pagination:  138-9     Citation Subset:  IM    
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MeSH Terms
Anti-N-Methyl-D-Aspartate Receptor Encephalitis / complications*,  therapy
Cyclophosphamide / therapeutic use
Diagnosis, Differential
Immunosuppressive Agents / therapeutic use
Methylprednisolone / therapeutic use
Plasma Exchange
Psychotic Disorders / etiology*,  therapy
Reg. No./Substance:
0/Immunosuppressive Agents; 8N3DW7272P/Cyclophosphamide; X4W7ZR7023/Methylprednisolone

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