Document Detail

An unusual association of a sellar gangliocytoma with a prolactinoma.
MedLine Citation:
PMID:  17440820     Owner:  NLM     Status:  MEDLINE    
The simultaneous occurrence of a hypothalamic and sellar gangliocytoma with a pituitary prolactinoma is very rare. The explanation for such an association is not known. We describe the case of a woman who had a coexisting adjacent pituitary prolactinoma and gangliocytoma within the same sellar mass. The tumor cells of the gangliocytoma demonstrated expression of enkephalin, a product of proopiomelanocortin known to be a prolactin secretagogue. We postulate that in this patient there may be a link between gangliocytoma enkephalin and prolactin hypersecretion.
Omar Serri; France Berthelet; Manon Bélair; Sophie Vallette; Sylvia L Asa
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pituitary     Volume:  11     ISSN:  1573-7403     ISO Abbreviation:  Pituitary     Publication Date:  2008  
Date Detail:
Created Date:  2008-01-28     Completed Date:  2009-06-11     Revised Date:  2009-06-26    
Medline Journal Info:
Nlm Unique ID:  9814578     Medline TA:  Pituitary     Country:  United States    
Other Details:
Languages:  eng     Pagination:  85-7     Citation Subset:  IM    
Departments of Medicine, Radiology and Pathology, CHUM Notre-Dame Hospital, University of Montreal, 1560 Sherbrooke East, Montreal, QC H2L 4M1, Canada.
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MeSH Terms
Chemotherapy, Adjuvant
Dopamine Agonists / therapeutic use
Enkephalins / secretion
Ganglioneuroma / pathology*,  secretion,  therapy
Hormone Replacement Therapy
Hypothalamic Neoplasms / pathology*,  secretion,  therapy
Magnetic Resonance Imaging
Neoplasms, Multiple Primary*
Neurosurgical Procedures
Pituitary Neoplasms / pathology*,  secretion,  therapy
Prolactin / secretion
Prolactinoma / pathology*,  secretion,  therapy
Sella Turcica / pathology*
Skull Neoplasms / pathology*,  secretion,  therapy
Treatment Outcome
Young Adult
Reg. No./Substance:
0/Dopamine Agonists; 0/Enkephalins; 9002-62-4/Prolactin

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