| An unsaturated aliphatic alcohol as a natural ligand for a mouse odorant receptor. | |
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MedLine Citation:
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PMID: 23314914 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We report the identification of a physiological receptor-volatile pair in the mouse olfactory system. By activity-guided fractionation of exocrine gland extracts and subsequent chemical analysis, (Z)-5-tetradecen-1-ol was identified as a natural ligand for a mouse odorant receptor. (Z)-5-tetradecen-1-ol is excreted into male mouse urine under androgen control and enhances urine attractiveness to female mice. This report is to our knowledge the first to describe natural product-based deorphanization of an odorant receptor. |
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Authors:
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Keiichi Yoshikawa; Hiroaki Nakagawa; Naoki Mori; Hidenori Watanabe; Kazushige Touhara |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-13 |
Journal Detail:
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Title: Nature chemical biology Volume: - ISSN: 1552-4469 ISO Abbreviation: Nat. Chem. Biol. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101231976 Medline TA: Nat Chem Biol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Applied Biological Chemistry, The University of Tokyo, Tokyo, Japan. |
| Data Bank Information | |
Bank Name/Acc. No.:
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PubChem-Substance/160649155; 160649159; 160649160; 160649161; 160649162; 160649158; 160649163; 160649164; 160649157; 160649156; 160649165; 160649166; 160649170; 160649169; 160649167; 160649168 |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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