Document Detail


An unsaturated aliphatic alcohol as a natural ligand for a mouse odorant receptor.
MedLine Citation:
PMID:  23314914     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We report the identification of a physiological receptor-volatile pair in the mouse olfactory system. By activity-guided fractionation of exocrine gland extracts and subsequent chemical analysis, (Z)-5-tetradecen-1-ol was identified as a natural ligand for a mouse odorant receptor. (Z)-5-tetradecen-1-ol is excreted into male mouse urine under androgen control and enhances urine attractiveness to female mice. This report is to our knowledge the first to describe natural product-based deorphanization of an odorant receptor.
Authors:
Keiichi Yoshikawa; Hiroaki Nakagawa; Naoki Mori; Hidenori Watanabe; Kazushige Touhara
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-13
Journal Detail:
Title:  Nature chemical biology     Volume:  -     ISSN:  1552-4469     ISO Abbreviation:  Nat. Chem. Biol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101231976     Medline TA:  Nat Chem Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Applied Biological Chemistry, The University of Tokyo, Tokyo, Japan.
Data Bank Information
Bank Name/Acc. No.:
PubChem-Substance/160649155;  160649159;  160649160;  160649161;  160649162;  160649158;  160649163;  160649164;  160649157;  160649156;  160649165;  160649166;  160649170;  160649169;  160649167;  160649168
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