Document Detail

The unripe cervix and its management for labour induction.
MedLine Citation:
PMID:  8363326     Owner:  NLM     Status:  MEDLINE    
Cervical state plays an important part in the outcome of induced labour. The mechanism governing the process of ripening, which is part of the continuum ending in labour, is still not fully understood, but is thought to involve several hormonal interactions including oestrogens, progesterone, and prostaglandins. The prostaglandins have been found to produce the best results for inducing labour when the cervix is unripe and are most effective when administered locally and most convenient when placed in the vagina as a viscous gel, wax pessary or slow release pessary. They are of benefit for labour induction in cases previously delivered by lower segment caesarean section, breech presentation, and multiple pregnancies. Hyperstimulation and fetal distress may occur and this might be reduced with the use of the controlled release hydrogel pessary. Newer approaches using an antiprogestin or recombinant relaxin are being explored in the hope that further improvements in outcome can be obtained.
I Z MacKenzie
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annals of the Academy of Medicine, Singapore     Volume:  22     ISSN:  0304-4602     ISO Abbreviation:  Ann. Acad. Med. Singap.     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-09-30     Completed Date:  1993-09-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7503289     Medline TA:  Ann Acad Med Singapore     Country:  SINGAPORE    
Other Details:
Languages:  eng     Pagination:  151-7     Citation Subset:  IM    
University of Oxford, John Radcliffe Hospital, UK.
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MeSH Terms
Administration, Intravaginal
Cervix Uteri* / drug effects,  physiology
Dehydroepiandrosterone / analogs & derivatives,  pharmacology,  therapeutic use
Dehydroepiandrosterone Sulfate
Dilatation and Curettage / instrumentation,  methods
Estrogens / pharmacology,  therapeutic use
Fetal Blood / chemistry
Labor, Induced / methods*
Mifepristone / pharmacology,  therapeutic use
Pregnancy Outcome
Prostaglandins / blood,  pharmacology,  therapeutic use
Relaxin / pharmacology,  therapeutic use
Reg. No./Substance:
0/Estrogens; 0/Gels; 0/Oxytocics; 0/Prostaglandins; 53-43-0/Dehydroepiandrosterone; 651-48-9/Dehydroepiandrosterone Sulfate; 84371-65-3/Mifepristone; 9002-69-1/Relaxin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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