Document Detail

A unique property of fetal bovine serum: high levels of protein-glutathione mixed disulfides.
MedLine Citation:
PMID:  67079     Owner:  NLM     Status:  MEDLINE    
Fetal bovine serum has been reported to delay or inhibit "spontaneous" neoplastic transformation in vitro as compared with all other sera tested. The present results indicate that fetal bovine serum is also unique in containing high levels of protein-glutathione mixed disulfides (3 to 7 microng glutathione as mixed disulfide per ml serum). The level of mixed disulfide appears to vary in accordance with the period of gestation of the fetal calves used to prepare the serum, decreasing below detectable levels (less than 0.2 microng per ml) with near-term fetal calves. Calf, adult bovine, fetal horse, and swine sera did not contain detectable levels of this type of mixed disulfide.
E A Bump; D J Reed
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  In vitro     Volume:  13     ISSN:  0073-5655     ISO Abbreviation:  In Vitro     Publication Date:  1977 Feb 
Date Detail:
Created Date:  1977-06-22     Completed Date:  1977-06-22     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0063733     Medline TA:  In Vitro     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  115-8     Citation Subset:  IM    
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MeSH Terms
Blood Chemical Analysis
Culture Media
Disulfides / analysis*
Fetal Blood / analysis*
Glutathione / analysis*
Species Specificity
alpha-Fetoproteins / analysis
Reg. No./Substance:
0/Culture Media; 0/Disulfides; 0/alpha-Fetoproteins; 70-18-8/Glutathione

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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