Document Detail

The unique properties of dipeptidyl-peptidase IV (DPP IV / CD26) and the therapeutic potential of DPP IV inhibitors.
MedLine Citation:
PMID:  10101215     Owner:  NLM     Status:  MEDLINE    
This review deals with the properties and functions of dipeptidyl peptidase IV (DPP IV, EC This membrane anchored ecto-protease has been identified as the leukocyte antigen CD26. The following aspects of DPP IV/CD26 will be discussed : the structure of DPP IV and the new family of serine proteases to which it belongs, the substrate specificity, the distribution in the human body, specific DPP IV inhibitors and the role of CD26 in the intestinal and renal handling of proline containing peptides, in cell adhesion, in peptide metabolism, in the immune system and in HIV infection. Especially the latest developments in the search for new inhibitors will be reported as well as the discovery of new natural substrates for DPP IV such as the glucagon-like peptides and the chemokines. Finally the therapeutical perspectives for DPP IV inhibitors will be discussed.
K Augustyns; G Bal; G Thonus; A Belyaev; X M Zhang; W Bollaert; A M Lambeir; C Durinx; F Goossens; A Haemers
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current medicinal chemistry     Volume:  6     ISSN:  0929-8673     ISO Abbreviation:  Curr. Med. Chem.     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-06-15     Completed Date:  1999-06-15     Revised Date:  2007-02-12    
Medline Journal Info:
Nlm Unique ID:  9440157     Medline TA:  Curr Med Chem     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  311-27     Citation Subset:  IM; X    
Department of Pharmaceutical Chemistry, University of Antwerp (UIA), Universiteitsplein 1, Antwerpen, B-2610, Belgium.
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MeSH Terms
Antigens, CD26 / drug effects*,  physiology*
Cell Adhesion
Cytokines / metabolism
Enzyme Inhibitors / chemistry,  pharmacology*,  therapeutic use
HIV Infections / enzymology
Immune System / metabolism
Intestines / metabolism
Kidney / metabolism
Neuropeptides / metabolism
Peptides / metabolism
Proline / metabolism
Substrate Specificity
Reg. No./Substance:
0/Cytokines; 0/Enzyme Inhibitors; 0/Neuropeptides; 0/Peptides; 147-85-3/Proline; EC, CD26

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