Document Detail

A unique plasma proteomic profiling with imbalanced fibrinogen cascade in patients with Kawasaki disease.
MedLine Citation:
PMID:  19170925     Owner:  NLM     Status:  MEDLINE    
Kawasaki disease (KD) is the leading cause of acquired heart disease during childhood in the developed countries. The mechanism and biomarkers of KD remain to be determined. In this study, we sought to elucidate potential plasma proteomic markers in KD patients in comparison to that in febrile controls. Plasma samples from KD patients and febrile controls were subjected to two-dimensional polyacrylamide gel electrophoresis analysis. Differential protein displays between KD patients and febrile controls were determined. Fibrinogen beta and gamma chains, alpha-1-antitrypsin (A1AT), CD5 antigen-like precursor (CD5L), and clusterin were increased in KD patients, whereas immunoglobulin free light chains were decreased, as compared with controls. The differential protein displays were validated with enzyme-linked immunosorbent assay tests. We found higher fibrinogen-related proteins (fibrinogen, A1AT, clusterin, and CD5L), along with a lower level of the immunoglobulin free light chains that involve fibrin degradation in KD. Results from this study showing a unique proteomic profiling with abnormal fibrinogen cascade may afford a good biomarker of KD and a better strategy to prevent cardiovascular complications of KD by correcting abnormal fibrin deposition or degradation.
Hong-Ren Yu; Ho-Chang Kuo; Jiunn-Ming Sheen; Lin Wang; I-Chun Lin; Chih-Lu Wang; Kuender D Yang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-01-12
Journal Detail:
Title:  Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology     Volume:  20     ISSN:  1399-3038     ISO Abbreviation:  Pediatr Allergy Immunol     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-16     Completed Date:  2010-01-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9106718     Medline TA:  Pediatr Allergy Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  699-707     Citation Subset:  IM    
Department of Pediatrics, Chang Gung Memorial Hospital - Kaohsiung Medical Center, Graduate Institute of Clinical Medical Science, Chang Gung University College of Medicine, Taiwan.
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MeSH Terms
Amino Acid Sequence
Blood Proteins / metabolism*
Child, Preschool
Electrophoresis, Gel, Two-Dimensional
Fibrinogen / chemistry,  metabolism*
Gene Expression Profiling*
Molecular Sequence Data
Mucocutaneous Lymph Node Syndrome / metabolism*
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
Reg. No./Substance:
0/Blood Proteins; 0/Proteome; 9001-32-5/Fibrinogen

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