| The unique paradigm of spirochete motility and chemotaxis. | |
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MedLine Citation:
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PMID: 22994496 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Spirochete motility is enigmatic: It differs from the motility of most other bacteria in that the entire bacterium is involved in translocation in the absence of external appendages. Using the Lyme disease spirochete Borrelia burgdorferi (Bb) as a model system, we explore the current research on spirochete motility and chemotaxis. Bb has periplasmic flagella (PFs) subterminally attached to each end of the protoplasmic cell cylinder, and surrounding the cell is an outer membrane. These internal helix-shaped PFs allow the spirochete to swim by generating backward-moving waves by rotation. Exciting advances using cryoelectron tomography are presented with respect to in situ analysis of cell, PF, and motor structure. In addition, advances in the dynamics of motility, chemotaxis, gene regulation, and the role of motility and chemotaxis in the life cycle of Bb are summarized. The results indicate that the motility paradigms of flagellated bacteria do not apply to these unique bacteria. |
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Authors:
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Nyles W Charon; Andrew Cockburn; Chunhao Li; Jun Liu; Kelly A Miller; Michael R Miller; Md A Motaleb; Charles W Wolgemuth |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annual review of microbiology Volume: 66 ISSN: 1545-3251 ISO Abbreviation: Annu. Rev. Microbiol. Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-09-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372370 Medline TA: Annu Rev Microbiol Country: United States |
Other Details:
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Languages: eng Pagination: 349-70 Citation Subset: IM |
Affiliation:
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Department of Microbiology, Immunology, and Cell Biology. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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