Document Detail


The unique paradigm of spirochete motility and chemotaxis.
MedLine Citation:
PMID:  22994496     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Spirochete motility is enigmatic: It differs from the motility of most other bacteria in that the entire bacterium is involved in translocation in the absence of external appendages. Using the Lyme disease spirochete Borrelia burgdorferi (Bb) as a model system, we explore the current research on spirochete motility and chemotaxis. Bb has periplasmic flagella (PFs) subterminally attached to each end of the protoplasmic cell cylinder, and surrounding the cell is an outer membrane. These internal helix-shaped PFs allow the spirochete to swim by generating backward-moving waves by rotation. Exciting advances using cryoelectron tomography are presented with respect to in situ analysis of cell, PF, and motor structure. In addition, advances in the dynamics of motility, chemotaxis, gene regulation, and the role of motility and chemotaxis in the life cycle of Bb are summarized. The results indicate that the motility paradigms of flagellated bacteria do not apply to these unique bacteria.
Authors:
Nyles W Charon; Andrew Cockburn; Chunhao Li; Jun Liu; Kelly A Miller; Michael R Miller; Md A Motaleb; Charles W Wolgemuth
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Annual review of microbiology     Volume:  66     ISSN:  1545-3251     ISO Abbreviation:  Annu. Rev. Microbiol.     Publication Date:  2012  
Date Detail:
Created Date:  2012-09-21     Completed Date:  2013-01-30     Revised Date:  2014-04-11    
Medline Journal Info:
Nlm Unique ID:  0372370     Medline TA:  Annu Rev Microbiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  349-70     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Borrelia burgdorferi / physiology*
Chemotaxis*
Flagella / physiology
Locomotion*
Grant Support
ID/Acronym/Agency:
AI078958/AI/NIAID NIH HHS; AI087946/AI/NIAID NIH HHS; AI093917/AI/NIAID NIH HHS; AI29743/AI/NIAID NIH HHS; AR060834/AR/NIAMS NIH HHS; GM0072004/GM/NIGMS NIH HHS; R01 AI087946/AI/NIAID NIH HHS; R01 AR060834/AR/NIAMS NIH HHS; R01 GM072004/GM/NIGMS NIH HHS
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