Document Detail


A unique microvascular phenotype shared by juvenile hemangiomas and human placenta.
MedLine Citation:
PMID:  11346333     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Juvenile hemangiomas are common, benign tumors, distinctive for their perinatal presentation, rapid growth during the first year of life, and subsequent involution. We recently reported that endothelia of hemangiomas highly express GLUT1, a glucose transporter normally restricted to endothelia with blood-tissue barrier function, as in brain and placenta. OBJECTIVE: To investigate possible further similarities between hemangioma and placental vessels. DESIGN: In a retrospective study of a variety of vascular tumors and anomalies, we assessed lesional immunoreactivities for the placenta-associated vascular antigens FcgammaRII, Lewis Y antigen (LeY), merosin, and GLUT1. SETTING: A university-affiliated pediatric hospital. MAIN OUTCOME MEASURE: Immunoreactivities scored for each antigen were summarized according to lesional type, compared with those of normal skin, brain, and placenta, and correlated with patient age, sex, and lesional location. RESULTS: All of 66 hemangiomas (patients aged 22 days to 7 years) showed intense immunoreactivity for FcgammaRII, merosin, LeY, and GLUT1. No immunoreactivities for these markers were seen in any of 26 vascular malformations, 4 granulation tissue specimens, 13 pyogenic granulomas, or in the tumor vasculature of 6 malignant tumors of nonvascular origin. Microvascular immunoreactivity for all 4 markers was observed in placental chorionic villi, but was absent in microvessels of normal skin and subcutis. Brain microvessels expressed only GLUT1 and merosin. CONCLUSIONS: A distinct constellation of tissue-specific markers is uniquely coexpressed by hemangiomas and placental microvessels. These findings imply a unique relationship between hemangioma and the placenta and suggest new hypotheses concerning the origin of these tumors.
Authors:
P E North; M Waner; A Mizeracki; R E Mrak; R Nicholas; J Kincannon; J Y Suen; M C Mihm
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of dermatology     Volume:  137     ISSN:  0003-987X     ISO Abbreviation:  Arch Dermatol     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-05-10     Completed Date:  2001-06-07     Revised Date:  2008-03-17    
Medline Journal Info:
Nlm Unique ID:  0372433     Medline TA:  Arch Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  559-70     Citation Subset:  AIM; IM    
Affiliation:
Department of Pediatric Pathology, Arkansas Children's Hospital, Little Rock 72202, USA.
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MeSH Terms
Descriptor/Qualifier:
Blood Vessels / abnormalities,  metabolism
Cerebrovascular Circulation
Child
Child, Preschool
Chorionic Villi / blood supply
Female
Glucose Transporter Type 1
Hemangioma / blood supply*,  metabolism
Humans
Immunohistochemistry
Infant
Infant, Newborn
Laminin / metabolism
Lewis Blood-Group System / metabolism
Microcirculation / physiology*
Monosaccharide Transport Proteins / metabolism
Phenotype
Placenta / blood supply*,  metabolism
Pregnancy
Retrospective Studies
Chemical
Reg. No./Substance:
0/Glucose Transporter Type 1; 0/Laminin; 0/Lewis Blood-Group System; 0/Lewis Y antigen; 0/Monosaccharide Transport Proteins; 0/SLC2A1 protein, human

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