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A unique family of endothelial cell polypeptide mitogens: the antigenic and receptor cross-reactivity of bovine endothelial cell growth factor, brain-derived acidic fibroblast growth factor, and eye-derived growth factor-II.
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MedLine Citation:
PMID:  2995409     Owner:  NLM     Status:  MEDLINE    
Bovine brain, hypothalamus, pituitary, and retina contain potent anionic polypeptide mitogens for endothelial cells. Immunological assays using murine monoclonal antibodies against bovine endothelial cell growth factor (ECGF) and radioreceptor assays using [125I]ECGF were performed to determine the cross-reactivity of ECGF with bovine acidic pI brain-derived fibroblast growth factor (acidic FGF) and bovine eye-derived growth factor-II [EDGF-II). We observed that acidic FGF and EDGF-II are recognized by anti-ECGF monoclonal antibodies and compete with [125I] ECGF for receptor occupancy. Furthermore, the biological activity of ECGF, acidic FGF, and EDGF-II is potentiated by the glycosaminoglycan, heparin. These results argue that ECGF, acidic FGF, and EDGF-II belong to a common family of polypeptide growth factors.
A B Schreiber; J Kenney; J Kowalski; K A Thomas; G Gimenez-Gallego; M Rios-Candelore; J Di Salvo; D Barritault; J Courty; Y Courtois; M Moenner; C Loret; W H Burgess; T Mehlman; R Friesel; W Johnson; T Maciag
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of cell biology     Volume:  101     ISSN:  0021-9525     ISO Abbreviation:  J. Cell Biol.     Publication Date:  1985 Oct 
Date Detail:
Created Date:  1985-11-07     Completed Date:  1985-11-07     Revised Date:  2010-03-31    
Medline Journal Info:
Nlm Unique ID:  0375356     Medline TA:  J Cell Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1623-6     Citation Subset:  IM    
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MeSH Terms
Antibodies, Monoclonal / immunology
Antibody Specificity
Binding, Competitive
Brain Chemistry*
Cell Division / drug effects
Cells, Cultured
Cross Reactions
Drug Synergism
Endothelial Growth Factors
Endothelium / drug effects
Epidermal Growth Factor / immunology,  metabolism
Fibroblast Growth Factors / immunology,  metabolism*
Growth Substances / classification*,  immunology,  metabolism*
Heparin / immunology,  metabolism,  pharmacology
Receptors, Cell Surface / metabolism
Grant Support
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Endothelial Growth Factors; 0/Growth Substances; 0/Proteins; 0/Receptors, Cell Surface; 0/eye-derived growth factor; 0/hypothalamus-derived growth factor; 62031-54-3/Fibroblast Growth Factors; 62229-50-9/Epidermal Growth Factor; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): J Cell Biol
ISSN: 0021-9525
ISSN: 1540-8140
Publisher: The Rockefeller University Press
Article Information
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Print publication date: Day: 1 Month: 10 Year: 1985
Volume: 101 Issue: 4
First Page: 1623 Last Page: 1626
ID: 2113927
Publisher Id: 86008483
PubMed Id: 2995409

A unique family of endothelial cell polypeptide mitogens: the antigenic and receptor cross-reactivity of bovine endothelial cell growth factor, brain-derived acidic fibroblast growth factor, and eye-derived growth factor-II

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