| A unique expression pattern of Tbx10 in the hindbrain as revealed by Tbx10(LacZ) allele. | |
| | |
MedLine Citation:
|
PMID: 20162674 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
To study the expression/function of Tbx10, a T-box gene, Tbx10(LacZ/+) mice were established by replacing the T-box coding region with a LacZ gene. X-gal staining showed that LacZ(+) cells were localized to two-cell populations in rhombomere 4 and rhombomere 6. No significant differences in the locations of LacZ(+) cells were found between Tbx10(LacZ/+) and Tbx10(LacZ/LacZ) mice, and the Tbx10(LacZ/LacZ) mice were viable and fertile. We found that the LacZ(+) cells are present in both embryonic and adult mice. Histological studies suggest that the rhombomere 4-derived LacZ(+) cells are a subpopulation of the ventral interneurons in the pons. |
| | |
Authors:
|
Xiao Dong Xue; Wataru Kimura; Bo Wang; Keisuke Hikosaka; Tatsuo Itakura; Tadayoshi Uezato; Masashi Matsuda; Haruhiko Koseki; Naoyuki Miura |
Related Documents
:
|
893404 - Isolation and characterization of a novel trisialoganglioside, gt1a, from human brain. 21273094 - Tacrolimus preserves vasomotor function and maintains vascular homeostasis. 12900764 - Attenuation of ganglioside gm1 accumulation in the brain of gm1 gangliosidosis mice by ... 3651504 - The mono- and difucosyl blood group b glycosphingolipids of rat large intestine differ ... 7953394 - Improved survival in simulated surgical infection with combined cytokine, antibiotic an... 3027204 - Concomitant enhancement of a cytoskeleton-associated 76,000-dalton protein and inhibiti... |
Publication Detail:
|
Type: Letter; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Genesis (New York, N.Y. : 2000) Volume: 48 ISSN: 1526-968X ISO Abbreviation: Genesis Publication Date: 2010 May |
Date Detail:
|
Created Date: 2010-05-12 Completed Date: 2010-08-20 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100931242 Medline TA: Genesis Country: United States |
Other Details:
|
Languages: eng Pagination: 295-302 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Alleles Animals Embryo, Mammalian / cytology, embryology, metabolism Female Gene Expression Profiling* Gene Expression Regulation, Developmental* Immunohistochemistry In Situ Hybridization Interneurons / cytology, metabolism Lac Operon / genetics Male Mice Mice, Inbred C57BL Mice, Inbred Strains Mice, Transgenic Mutation Pons / cytology, embryology, metabolism Rhombencephalon / cytology, embryology, metabolism* T-Box Domain Proteins / genetics*, metabolism beta-Galactosidase / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/T-Box Domain Proteins; 0/Tbx10 protein, mouse; EC 3.2.1.23/beta-Galactosidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Deregulation of the cell cycle by breast tumor kinase (Brk).
Next Document: Three inhibitors of FGF receptor, ERK and GSK3 establishes germline-competent embryonic stem cells o...