| A unique cardiac cytosolic acyltransferase with preferential selectivity for fatty acids that form cyclooxygenase/lipoxygenase metabolites and reverse essential fatty acid deficiency. | |
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MedLine Citation:
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PMID: 3927984 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The rabbit heart contains a cytosolic enzyme which selectively incorporates polyunsaturated fatty acids into phosphatidylcholine. This unique acyltransferase is selective for fatty acids, thus far tested, that are substrates for cyclooxygenase or lipoxygenase (i.e., arachidonic, eicosapentaenoic, linoleic and dihomo-gamma-linoleic acids) or which reverse the symptoms of essential fatty acid deficiency (columbinic acid). On the other hand, palmitic, oleic, 5,8,11-eicosatrienoic (n-9, Mead acid), and docosatetraenoic acid (n-6, adrenic acid) were not incorporated in phospholipids by the cytosolic acyltransferase. No such fatty acid selectivity was exhibited by the cytosolic acyl-CoA synthetase or by the acyltransferase activities present in cardiac microsomes and mitochondria. |
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Authors:
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P Needleman; A Wyche; H Sprecher; W J Elliott; A Evers |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Biochimica et biophysica acta Volume: 836 ISSN: 0006-3002 ISO Abbreviation: Biochim. Biophys. Acta Publication Date: 1985 Sep |
Date Detail:
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Created Date: 1985-10-18 Completed Date: 1985-10-18 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0217513 Medline TA: Biochim Biophys Acta Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 267-73 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acyltransferases
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metabolism* Animals Cytosol / enzymology Fatty Acids / metabolism* Fatty Acids, Essential / deficiency, metabolism Fatty Acids, Unsaturated / metabolism Lipoxygenase / metabolism* Male Microsomes / enzymology Mitochondria, Heart / enzymology Myocardium / enzymology* Prostaglandin-Endoperoxide Synthases / metabolism* Rabbits Substrate Specificity |
| Grant Support | |
ID/Acronym/Agency:
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HL 17646/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Fatty Acids, Essential; 0/Fatty Acids, Unsaturated; EC 1.13.11.12/Lipoxygenase; EC 1.14.99.1/Prostaglandin-Endoperoxide Synthases; EC 2.3.-/Acyltransferases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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