Document Detail


A unique cardiac cytosolic acyltransferase with preferential selectivity for fatty acids that form cyclooxygenase/lipoxygenase metabolites and reverse essential fatty acid deficiency.
MedLine Citation:
PMID:  3927984     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The rabbit heart contains a cytosolic enzyme which selectively incorporates polyunsaturated fatty acids into phosphatidylcholine. This unique acyltransferase is selective for fatty acids, thus far tested, that are substrates for cyclooxygenase or lipoxygenase (i.e., arachidonic, eicosapentaenoic, linoleic and dihomo-gamma-linoleic acids) or which reverse the symptoms of essential fatty acid deficiency (columbinic acid). On the other hand, palmitic, oleic, 5,8,11-eicosatrienoic (n-9, Mead acid), and docosatetraenoic acid (n-6, adrenic acid) were not incorporated in phospholipids by the cytosolic acyltransferase. No such fatty acid selectivity was exhibited by the cytosolic acyl-CoA synthetase or by the acyltransferase activities present in cardiac microsomes and mitochondria.
Authors:
P Needleman; A Wyche; H Sprecher; W J Elliott; A Evers
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  836     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1985 Sep 
Date Detail:
Created Date:  1985-10-18     Completed Date:  1985-10-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  267-73     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acyltransferases / metabolism*
Animals
Cytosol / enzymology
Fatty Acids / metabolism*
Fatty Acids, Essential / deficiency,  metabolism
Fatty Acids, Unsaturated / metabolism
Lipoxygenase / metabolism*
Male
Microsomes / enzymology
Mitochondria, Heart / enzymology
Myocardium / enzymology*
Prostaglandin-Endoperoxide Synthases / metabolism*
Rabbits
Substrate Specificity
Grant Support
ID/Acronym/Agency:
HL 17646/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Fatty Acids, Essential; 0/Fatty Acids, Unsaturated; EC 1.13.11.12/Lipoxygenase; EC 1.14.99.1/Prostaglandin-Endoperoxide Synthases; EC 2.3.-/Acyltransferases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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