Document Detail

The union of anti-CD34 antibody can improve the performance of drug-eluting stents.
MedLine Citation:
PMID:  22162277     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The authors investigate whether the combination of anti-CD34 antibody with DES is win-win cooperation.
BACKGROUND: DES may reduce the risk of restenosis compared to bare-metal stents (BMS), but they were found to inhibit the healing process of intima.
METHODS: Fifteen BMS, 17 DES, and 16 combined anti-CD34 antibody and DES were randomly implanted in the coronary arteries of 22 minipigs. Ten minipigs were followed up to 2 weeks. The stenting coronary segments were examined by histological examination and scanning electron microscopy after in vivo coronary angiography and intracoronary optical coherence tomography (OCT) examinations. The other 12 minipigs were followed up to 3 months. Coronary angiography and intracoronary OCT examination were performed in vivo and histological examination was performed on the stenting coronary segments.
RESULTS: After 2 weeks, the neointimal covering level of the DES was lower than that in BMS, but the covering level of the combined stents was even better than the BMS. After 3 months, neointimal hyperplasia was significant in the BMS, but not in the other two types of stents. The in-stent late lumen loss of the combined stents even showed a decreasing tendency when compared with the DES.
CONCLUSION: The combination of anti-CD34 antibody and DES can not only well offset the short-term inhibitory effect on re-endothelialization but also slightly enhance the long-term antiproliferative effect.
Xing-Sheng Yang; Hua-Gang Zhu; Zhan-Jiang Yu; Fang Ren; Yong-Qiang Chen; Xi Wu; Zheng-Cai Zhang; Li-Jie Zhang; Shu-Zheng Lu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-12-08
Journal Detail:
Title:  Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions     Volume:  79     ISSN:  1522-726X     ISO Abbreviation:  Catheter Cardiovasc Interv     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-18     Completed Date:  2012-08-13     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  100884139     Medline TA:  Catheter Cardiovasc Interv     Country:  United States    
Other Details:
Languages:  eng     Pagination:  972-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Wiley Periodicals, Inc.
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MeSH Terms
Angioplasty, Balloon, Coronary / adverse effects,  instrumentation*
Antibodies / pharmacology*
Antigens, CD34 / immunology*
Cardiovascular Agents / administration & dosage
Cell Proliferation / drug effects
Coronary Angiography
Coronary Restenosis / diagnosis,  etiology,  immunology,  prevention & control*
Coronary Vessels / drug effects*,  immunology,  pathology
Drug-Eluting Stents*
Microscopy, Electron, Scanning
Neointima / etiology,  prevention & control
Prosthesis Design
Sirolimus / administration & dosage
Swine, Miniature
Time Factors
Tomography, Optical Coherence
Reg. No./Substance:
0/Antibodies; 0/Antigens, CD34; 0/Cardiovascular Agents; 0/Metals; W36ZG6FT64/Sirolimus

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