Document Detail

An unexpected parallelism between Vitamin A and PCBs in seal milk.
MedLine Citation:
PMID:  15145227     Owner:  NLM     Status:  MEDLINE    
Bioaccumulating pollutants such as polychlorinated biphenyls (PCBs) induce a range of adverse effects in mammals. Vitamin A metabolism is prone to such pollutant disruption which may be particularly harmful for young animals. During lactation, maternal PCBs are transferred to the offspring through the milk. Seal milk is very fatty and consequently contains large amounts of these persistent lipophilic contaminants. In the present study, we investigated the relationships between PCBs and Vitamins A and E during lactation, in free-ranging grey seals, using longitudinal samples of milk and blubber. We discovered that, unlike Vitamin E or triglycerides, the dynamics of Vitamin A matches closely those of PCBs in milk throughout lactation. Levels of Vitamin A and PCBs remain constant during the first half of lactation and then increase at late lactation, indicating that pups ingesting higher levels of PCBs also ingest higher amounts of Vitamin A.
Cathy Debier; P P Pomeroy; J-P Thomé; E Mignolet; T de Tillesse; Y Larondelle
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Aquatic toxicology (Amsterdam, Netherlands)     Volume:  68     ISSN:  0166-445X     ISO Abbreviation:  Aquat. Toxicol.     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-05-17     Completed Date:  2004-08-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8500246     Medline TA:  Aquat Toxicol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  179-83     Citation Subset:  IM    
Unité de Biochimie de la Nutrition, Institut des Sciences de la Vie, Université catholique de Louvain, Croix du Sud 2/8, B-1348 Louvain-la-Neuve, Belgium.
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MeSH Terms
Adipose Tissue / chemistry
Chromatography, High Pressure Liquid
Lactation / metabolism*
Maternal Exposure*
Milk / chemistry*,  metabolism
Polychlorinated Biphenyls / pharmacokinetics*
Seals, Earless / metabolism*
Time Factors
Vitamin A / metabolism*,  pharmacokinetics
Reg. No./Substance:
0/Polychlorinated Biphenyls; 11103-57-4/Vitamin A

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