Document Detail

An unconventional myosin in Drosophila reverses the default handedness in visceral organs.
MedLine Citation:
PMID:  16598258     Owner:  NLM     Status:  MEDLINE    
The internal organs of animals often have left-right asymmetry. Although the formation of the anterior-posterior and dorsal-ventral axes in Drosophila is well understood, left-right asymmetry has not been extensively studied. Here we find that the handedness of the embryonic gut and the adult gut and testes is reversed (not randomized) in viable and fertile homozygous Myo31DF mutants. Myo31DF encodes an unconventional myosin, Drosophila MyoIA (also referred to as MyoID in mammals; refs 3, 4), and is the first actin-based motor protein to be implicated in left-right patterning. We find that Myo31DF is required in the hindgut epithelium for normal embryonic handedness. Disruption of actin filaments in the hindgut epithelium randomizes the handedness of the embryonic gut, suggesting that Myo31DF function requires the actin cytoskeleton. Consistent with this, we find that Myo31DF colocalizes with the cytoskeleton. Overexpression of Myo61F, another myosin I (ref. 4), reverses the handedness of the embryonic gut, and its knockdown also causes a left-right patterning defect. These two unconventional myosin I proteins may have antagonistic functions in left-right patterning. We suggest that the actin cytoskeleton and myosin I proteins may be crucial for generating left-right asymmetry in invertebrates.
Shunya Hozumi; Reo Maeda; Kiichiro Taniguchi; Maiko Kanai; Syuichi Shirakabe; Takeshi Sasamura; Pauline Spéder; Stéphane Noselli; Toshiro Aigaki; Ryutaro Murakami; Kenji Matsuno
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nature     Volume:  440     ISSN:  1476-4687     ISO Abbreviation:  Nature     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-04-06     Completed Date:  2006-04-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0410462     Medline TA:  Nature     Country:  England    
Other Details:
Languages:  eng     Pagination:  798-802     Citation Subset:  IM    
Department of Biological Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan.
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MeSH Terms
Actins / metabolism
Body Patterning*
Cytoskeleton / metabolism
Digestive System / anatomy & histology,  embryology,  metabolism
Digestive System Abnormalities / embryology,  metabolism
Drosophila / anatomy & histology,  embryology*,  genetics,  metabolism*
Mutation / genetics
Myosin Type I / genetics,  metabolism*
Testis / abnormalities,  anatomy & histology,  embryology,  metabolism
Reg. No./Substance:
0/Actins; EC 3.6.1.-/Myosin Type I

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