Document Detail

The ultrastructure of nuclear inclusions in the giant-cell tumor of bone.
MedLine Citation:
PMID:  2726607     Owner:  NLM     Status:  MEDLINE    
The ultrastructural study of three cases of giant-cell tumor of bone showed two types of nuclear inclusions. The first type, common to giant cells and stromal cells was granular, and sometimes associated with a fibrillar pattern observed only in giant cells. The second type was represented by nuclear bodies, encountered mostly in the stromal cells. The nuclear bodies were made up of a granular core enveloped in a multilayered coat. The nature of these nuclear inclusions might be viral and thus a viral pathogenesis of the giant-cell tumor of bone is discussed.
A Negoescu; E Mandache
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pathology, research and practice     Volume:  184     ISSN:  0344-0338     ISO Abbreviation:  Pathol. Res. Pract.     Publication Date:  1989 Apr 
Date Detail:
Created Date:  1989-07-12     Completed Date:  1989-07-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7806109     Medline TA:  Pathol Res Pract     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  410-7     Citation Subset:  IM    
Department of Electron Microscopy, V. Babes Institute, Bucharest, Romania.
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MeSH Terms
Bone Neoplasms / ultrastructure*
Cell Nucleus / ultrastructure*
Giant Cell Tumors / ultrastructure*
Inclusion Bodies, Viral / ultrastructure*
Microscopy, Electron
Middle Aged

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