Document Detail

The ultrastructure of experimental aneurysms in rabbits.
MedLine Citation:
PMID:  4000718     Owner:  NLM     Status:  MEDLINE    
The fine structure of tissue from 6 berry aneurysms, 7 saccular aneurysms and 2 fusiform aneurysms produced by microvascular surgery in rabbits was examined. The rabbits were maintained on a stock diet and sacrificed from 3 mth to 3 yr 10 mth postoperatively. The aneurysmal walls exhibited thickening of the intimal type with progressive destruction of normal architecture and degenerative and necrotic changes in the smooth muscle cells. Thickening, lamination, redundancy, reticulation and separation of basement membranes about muscle cells and an abundance of matrix vesicles and cell debris were prominent features. In several aneurysms, extracellular lipid, cholesterol clefts and lipophages were observed and fibrin was found in 4 aneurysmal walls. These vascular lesions evinced remarkable similarity to the degenerative changes in experimental arteriovenous aneurysms, human cerebral aneurysms and spontaneous atherosclerosis.
W E Stehbens
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pathology     Volume:  17     ISSN:  0031-3025     ISO Abbreviation:  Pathology     Publication Date:  1985 Jan 
Date Detail:
Created Date:  1985-06-26     Completed Date:  1985-06-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0175411     Medline TA:  Pathology     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  87-95     Citation Subset:  IM    
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MeSH Terms
Aneurysm / pathology*
Aortic Aneurysm / pathology
Carotid Artery Diseases / pathology
Intracranial Aneurysm / pathology
Microscopy, Electron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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