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The ultrastructure of cardiac desnosomes in the toad and their relationship to the intercalated disc.
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MedLine Citation:
PMID:  13708707     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The fine structure of desmosomes and intercalated discs in the toad heart is discussed. A definite relationship between the dense components of these structures and the dense region of the Z band is demonstrated. The dense region of the Z band characteristically widens at its approach to the plasma membrane, and often terminates beneath it in a distinct discoidal plaque. Cardiac desmosomes appear to be structures which result from the intimate apposition of plaques of Z band material. These desmosomes retain the Z band function as sites of attachment for myofilaments. The suggestion is made that rotation of a desmosome through 90 degrees and splitting of filaments from the adjacent sarcomere could result in the formation of a simple step-like intercalated disc. Intermediate stages in this process are illustrated. Complex discs present in the toad probably represent the alignment of groups of simple discs produced by contractile forces. Possible physiologic functions of the disc and desmosome are discussed. Other morphologic features of toad cardiac cells include a distinct amorphous outer coat to the sarcolemma, a prominent N band, and a granular sarcoplasm with poorly developed reticulum.
Authors:
P M GRIMLEY; G A EDWARDS
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of biophysical and biochemical cytology     Volume:  8     ISSN:  0095-9901     ISO Abbreviation:  J Biophys Biochem Cytol     Publication Date:  1960 Oct 
Date Detail:
Created Date:  1961-12-01     Completed Date:  1998-11-01     Revised Date:  2010-06-22    
Medline Journal Info:
Nlm Unique ID:  17840020R     Medline TA:  J Biophys Biochem Cytol     Country:  Not Available    
Other Details:
Languages:  eng     Pagination:  305-18     Citation Subset:  OM    
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MeSH Terms
Descriptor/Qualifier:
Heart / anatomy & histology*
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): J Biophys Biochem Cytol
ISSN: 0095-9901
Publisher: The Rockefeller University Press
Article Information
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Copyright © Copyright 1961 by The Rockefeller Institute Press
Received Day: 12 Month: 8 Year: 1959
Print publication date: Day: 1 Month: 10 Year: 1960
Volume: 8 Issue: 2
First Page: 305 Last Page: 318
ID: 2224943
PubMed Id: 13708707

THE ULTRASTRUCTURE OF CARDIAC DESMOSOMES IN THE TOAD AND THEIR RELATIONSHIP TO THE INTERCALATED DISC
Philip M. Grimley
George A. Edwards
From The Division of Laboratories and Research, New York State Department of Health, Albany


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