| An ultrastructural morphometric comparison of the peripheral with the hilar air-blood barrier of dog lung. | |
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MedLine Citation:
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PMID: 6476419 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Excised and isolated perfused lungs are frequently used as models for studies of fluid flow and membrane transport. Regional variations of the air and blood vascular compartments of the lung have been recognized to result from gravitational effects. This ultrastructural morphometric study considered the components of the air-blood barriers of the peripheral and hilar regions of excised dog lungs. The lungs of three mongrel dogs were fixed by endotracheal instillation of glutaraldehyde and immersion in fixative. Stratified random sampling, point counting volumetry, and line intercept counts were used to determine the thicknesses of the air-blood barrier and the epithelial, interstitial, and endothelial compartments. Point counting volumetry also established the volume density of the alveolar spaces. The morphometric values for structures within the periphery were statistically compared to those within the hilar region by Student's t-test. Endotracheal and immersion fixation as used in this study, combined with stratified random sampling, equalized regional differences in the alveolar lumen volume and air-blood barrier thickness. With these conditions no significant differences in the volume densities of the epithelial and endothelial cells and the interstitium of the air-blood barrier were identified when those of the hilum were compared to those of the periphery. |
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Authors:
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P B Berendsen; A B Ritter; D O DeFouw |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Anatomical record Volume: 209 ISSN: 0003-276X ISO Abbreviation: Anat. Rec. Publication Date: 1984 Aug |
Date Detail:
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Created Date: 1984-10-23 Completed Date: 1984-10-23 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370540 Medline TA: Anat Rec Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 535-40 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Capillaries / ultrastructure Connective Tissue / ultrastructure Dogs / anatomy & histology* Endothelium / ultrastructure Epithelium / ultrastructure Lung / blood supply, physiology, ultrastructure* Male Microscopy, Electron Pulmonary Alveoli / blood supply, ultrastructure* |
| Grant Support | |
ID/Acronym/Agency:
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HL-12879/HL/NHLBI NIH HHS; HL-19571/HL/NHLBI NIH HHS; HL-28372/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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