Document Detail


The ubiquity of memory retrieval deficits in patients with frontal-striatal dysfunction.
MedLine Citation:
PMID:  16340392     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE AND BACKGROUND: Previous studies have shown that patients with frontal-striatal dysfunction demonstrate improved performance on tests of recognition memory relative to free recall memory, suggesting deficits in retrieval processes. Not all studies, however, have indicated that all patients with frontal-striatal dysfunction display this profile. In this study, we examined the ubiquity of this "retrieval deficit" profile in a relatively large sample of patients with Parkinson disease (PD) or Huntington disease (HD). METHODS: Participants included 150 patients with PD and 65 patients with HD. Patients were classified as demonstrating a retrieval deficit or not based on a comparison of their standardized performances on the Recognition Discriminability and Long-Delay Free Recall indices from the California Verbal Learning Test. RESULTS: Results indicated that 1) a retrieval deficit was more prevalent in patients with HD than PD, 2) this group difference emerged only in patients with at least a mild level of global cognitive impairment, and 3) even when the profile did emerge more frequently in patients with HD, it was present in only 44% of the patients. CONCLUSIONS: These findings suggest that not all patient groups with frontal-striatal dysfunction display a retrieval deficit profile, but in groups that do (ie, patients with HD), it is more likely to appear in individuals with greater cognitive impairment.
Authors:
Vanessa S Zizak; J Vincent Filoteo; Katherine L Possin; John A Lucas; Laurie M Rilling; Jennifer D Davis; Guerry Peavy; Andus Wong; David P Salmon
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology     Volume:  18     ISSN:  1543-3633     ISO Abbreviation:  Cogn Behav Neurol     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-12-12     Completed Date:  2006-02-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  101167278     Medline TA:  Cogn Behav Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  198-205     Citation Subset:  IM    
Affiliation:
University of California, San Diego, CA 92161, USA.
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MeSH Terms
Descriptor/Qualifier:
Aged
Female
Frontal Lobe / physiopathology*
Humans
Huntington Disease / complications,  physiopathology,  psychology
Male
Memory / physiology
Memory Disorders / etiology,  physiopathology*
Mental Recall / physiology
Neostriatum / physiopathology*
Neuropsychological Tests
Parkinson Disease / complications,  physiopathology,  psychology
Recognition (Psychology) / physiology
Verbal Learning
Grant Support
ID/Acronym/Agency:
R01-AG12963/AG/NIA NIH HHS; R01-NS41372/NS/NINDS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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