| The ubiquitin specific protease 19 (USP19) regulates the hypoxia inducible factor 1α (HIF-1α) during hypoxia. | |
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MedLine Citation:
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PMID: 22128162 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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A proper cellular adaptation to low oxygen levels is essential for processes such as development, growth, metabolism and angiogenesis. The response to decrease in oxygen supply, referred to as hypoxia, is also involved in numerous human diseases including cancer, inflammatory conditions and vascular disease. The hypoxia inducible factor 1-α (HIF-1α), a key player in the hypoxic response, is kept under stringent regulation. At normoxia the levels are kept low as a consequence of the efficient degradation by the ubiquitin-proteasome system and in response to hypoxia the degradation is blocked and the accumulating HIF-1α promotes a transcriptional response essential for proper adaptation and survival. Here we show that the ubiquitin specific protease-19 (USP19) interacts with components of the hypoxia pathway including HIF-1α and rescues it from degradation independent of its catalytic activity. In the absence of USP19, cells fail to mount an appropriate response to hypoxia, indicating an important role for this enzyme in normal or pathological conditions. |
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Authors:
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Mikael Altun; Bin Zhao; Kelly Velasco; Haiyin Liu; Gerco Hassink; Julia Paschke; Teresa Pereira; Kristina Lindsten |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-29 |
Journal Detail:
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Title: The Journal of biological chemistry Volume: - ISSN: 1083-351X ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2985121R Medline TA: J Biol Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Karolinska Institutet, Sweden. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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