Document Detail

A typical bacterial ornithine-containing lipid Nalpha-(D)-[3-(hexadecanoyloxy)hexadecanoyl]-ornithine is a strong stimulant for macrophages and a useful adjuvant.
MedLine Citation:
PMID:  10030549     Owner:  NLM     Status:  MEDLINE    
Nalpha-[3-(Hexadecanoyloxy)hexadecanoyl]-ornithine is a typical bacterial ornithine-containing lipid (OL). The configuration of the 3-hydroxy fatty acids in the OL was proved to be D by using HPLC with chiral column. For this analysis, Nalpha-(D or L)-[3-(hexadecanoyloxy)hexadecanoyl]-L-ornithine were synthesized and used as standards. The typical bacterial OL, as well as the synthesized one, exhibited strong interleukin-1- and prostaglandin E2-inducing activities, and further, it induced the production of high IgG anti-tetanus toxoid antibodies in mice. The typical OL is expected to be utilized as a nontoxic, potent adjuvant.
Y Kawai; Y Nakagawa; T Matuyama; K Akagawa; K Itagawa; K Fukase; S Kusumoto; M Nishijima; I Yano
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  FEMS immunology and medical microbiology     Volume:  23     ISSN:  0928-8244     ISO Abbreviation:  FEMS Immunol. Med. Microbiol.     Publication Date:  1999 Jan 
Date Detail:
Created Date:  1999-08-11     Completed Date:  1999-08-11     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9315554     Medline TA:  FEMS Immunol Med Microbiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  67-73     Citation Subset:  IM    
Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases, Tokyo, Japan.
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MeSH Terms
Adjuvants, Immunologic*
Gram-Negative Bacteria / chemistry*,  immunology
Immunoglobulin G / blood
Interleukin-1 / biosynthesis
Lipids / chemistry,  immunology*,  isolation & purification
Macrophage Activation
Macrophages, Peritoneal / immunology
Ornithine / analysis*
Prostaglandins E / biosynthesis
Spectrometry, Mass, Fast Atom Bombardment
Tetanus Toxoid / immunology
Reg. No./Substance:
0/3-(hexadecanoyloxy)hexadecanoyl-ornithine; 0/Adjuvants, Immunologic; 0/Immunoglobulin G; 0/Interleukin-1; 0/Lipids; 0/Prostaglandins E; 0/Tetanus Toxoid; 7006-33-9/Ornithine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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