Document Detail


A two-year longitudinal reference range study for selected serum enzymes in a population more than 60 years of age.
MedLine Citation:
PMID:  6146645     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The reference ranges for alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), and creatine kinase (CK) in a population greater than 60 years were studied using commercially available reagents. All ranges except those for AST and ALT in women were higher than the ranges found in 20-50-year-old adults. A two-year longitudinal study indicated that individuals who had values above those found in younger adults did not show a greater incidence of disease than did individuals who had values in the lower portion of the distribution curve. Comparison of enzyme values at the beginning and at the end of the two-year study showed that mean ALP, AST, ALT, and LDH values (except for ALT values in men) increased gradually. It was concluded from these two findings that the higher values observed for the aging population were a result of the normal aging process, and thus these values were included in the reference range for this population. The range for CK in individuals greater than 60 years was also higher than that found for younger adults, but the mean value of the group was lower, except in women aged 60-69 years, in whom the mean value showed a slight increase over that found for normal adult women. This was believed to be the result of two independent processes; an increase in enzyme activity due to aging and a decrease in enzyme activity due to reduction in muscle mass as a result of the decreased muscular activity of some volunteers during retirement.
Authors:
N W Tietz; D R Wekstein; D F Shuey; G A Brauer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American Geriatrics Society     Volume:  32     ISSN:  0002-8614     ISO Abbreviation:  J Am Geriatr Soc     Publication Date:  1984 Aug 
Date Detail:
Created Date:  1984-09-07     Completed Date:  1984-09-07     Revised Date:  2008-03-10    
Medline Journal Info:
Nlm Unique ID:  7503062     Medline TA:  J Am Geriatr Soc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  563-70     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Aged
Aging*
Alanine Transaminase / blood*
Alkaline Phosphatase / blood*
Aspartate Aminotransferases / blood*
Creatine Kinase / blood
Female
Health Status
Humans
L-Lactate Dehydrogenase / blood*
Longitudinal Studies
Male
Middle Aged
Reference Values
Sex Factors
gamma-Glutamyltransferase / blood
Chemical
Reg. No./Substance:
EC 1.1.1.27/L-Lactate Dehydrogenase; EC 2.3.2.2/gamma-Glutamyltransferase; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase; EC 2.7.3.2/Creatine Kinase; EC 3.1.3.1/Alkaline Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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