Document Detail

The two-syndrome concept: origins and current status.
MedLine Citation:
PMID:  2863873     Owner:  NLM     Status:  MEDLINE    
The two-syndrome concept postulates two "dimensions of pathology" underlying schizophrenia--a reversible (and potentially neuroleptic-responsive) component and a sometimes progressive and relatively irreversible component associated with the deficit state and poor long-term outcome. Negative symptoms (narrowly defined) appear to be more closely associated with the latter component (the type II syndrome), as also are cognitive impairments, abnormal involuntary movements, and behavioral deterioration. This syndrome is assumed to be more closely related than the type I syndrome of positive symptoms to the structural brain changes inferred from pneumoencephalograms, computed tomography scans, and recent post-mortem studies. However, since both syndromes often occur in the same patient--sometimes at the same point in time--they presumably have the same etiology.
T J Crow
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Schizophrenia bulletin     Volume:  11     ISSN:  0586-7614     ISO Abbreviation:  Schizophr Bull     Publication Date:  1985  
Date Detail:
Created Date:  1985-10-10     Completed Date:  1985-10-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0236760     Medline TA:  Schizophr Bull     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  471-86     Citation Subset:  IM    
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MeSH Terms
Antipsychotic Agents / therapeutic use
Attention / drug effects
Delirium, Dementia, Amnestic, Cognitive Disorders / psychology
Drive / drug effects
Mood Disorders / psychology
Neuropsychological Tests
Schizophrenia / diagnosis*,  drug therapy,  etiology
Schizophrenic Language
Schizophrenic Psychology*
Social Adjustment
Reg. No./Substance:
0/Antipsychotic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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