Document Detail

A two-step schedule for the treatment of actinomycotic mycetomas.
MedLine Citation:
PMID:  11200840     Owner:  NLM     Status:  MEDLINE    
Actinomycotic mycetomas usually respond slowly to treatment with antibiotics. In an attempt to hasten clinical resolution, we used a 2-step regimen consisting of an intensive phase of therapy with penicillin, gentamycin and co-trimoxazole for 5-7 weeks, followed by maintenance therapy with amoxicillin and co-trimoxazole. Seven patients were treated, all of whom showed significant reduction in discharge and swelling after the intensive phase. Maintenance therapy was continued for 2-5 months after the lesions became completely inactive. Five patients completed maintenance therapy, which was given for 6-16 months (mean 10.7 months), and remained free of disease during a mean post-treatment follow-up period of 6.4 months. The other 2 patients also responded satisfactorily and continue to receive maintenance therapy. Side-effects necessitating a modification of the treatment schedule occurred in 2 patients but reversed on discontinuation of the drugs responsible. This treatment schedule produces a rapid clinical response during the initial, intensive phase and promotes compliance with the longer maintenance phase of treatment necessary to achieve a complete cure.
M Ramam; T Garg; P D'Souza; K K Verma; B K Khaitan; M K Singh; U Banerjee
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta dermato-venereologica     Volume:  80     ISSN:  0001-5555     ISO Abbreviation:  Acta Derm. Venereol.     Publication Date:    2000 Sep-Oct
Date Detail:
Created Date:  2001-01-25     Completed Date:  2001-05-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370310     Medline TA:  Acta Derm Venereol     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  378-80     Citation Subset:  IM    
Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi.
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MeSH Terms
Actinomycosis / diagnosis,  drug therapy*
Amoxicillin / therapeutic use
Drug Administration Schedule
Drug Therapy, Combination / therapeutic use*
Gentamicins / therapeutic use
Long-Term Care
Middle Aged
Mycetoma / diagnosis,  drug therapy*
Penicillins / therapeutic use
Trimethoprim-Sulfamethoxazole Combination / therapeutic use
Reg. No./Substance:
0/Gentamicins; 0/Penicillins; 26787-78-0/Amoxicillin; 8064-90-2/Trimethoprim-Sulfamethoxazole Combination

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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