Document Detail

The two mature transcripts of the chick calcitonin gene are expressed within the central nervous system during embryogenesis.
MedLine Citation:
PMID:  9784613     Owner:  NLM     Status:  MEDLINE    
Calcitonin mRNA and calcitonin gene-related peptide (CGRP) mRNA both are generated from the calcitonin gene because of tissue-specific alternative splicing of the primary transcript. It is currently established that, of the two mature transcripts, calcitonin mRNA is far the predominant transcript produced in thyroid C-cells whereas only CGRP mRNA is produced in the nervous system. However, here we provide evidence that the two splicing forms of the chick calcitonin primary transcript are found within the developing central nervous system, although displaying specific patterns of expression. While CGRP mRNA is first expressed in motor neurons at rather advanced stages of embryogenesis, calcitonin mRNA is expressed in the floor plate and dorsal rhombencephalon from earliest stages.
J Terrado; I Gerrikagoitia; D Raldúa; V Sorribas; L Martínez-Millán; M Sarasa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Mechanisms of development     Volume:  77     ISSN:  0925-4773     ISO Abbreviation:  Mech. Dev.     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1999-01-28     Completed Date:  1999-01-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9101218     Medline TA:  Mech Dev     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  81-4     Citation Subset:  IM    
Copyright Information:
Copyright 1998 Elsevier Science Ireland Ltd. All Rights Reserved.
Laboratory of Neurobiology, Faculty of Veterinary Sciences, University of Zaragoza, Miguel Servet 177, E-50013, Zaragoza, Spain.
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MeSH Terms
Calcitonin / genetics*
Calcitonin Gene-Related Peptide / genetics*
Central Nervous System / embryology,  metabolism*
Chick Embryo
Embryo, Nonmammalian / metabolism*
Embryonic Development
Gene Expression Regulation, Developmental
In Situ Hybridization
RNA, Messenger / genetics,  metabolism
Transcription, Genetic
Reg. No./Substance:
0/RNA, Messenger; 83652-28-2/Calcitonin Gene-Related Peptide; 9007-12-9/Calcitonin

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