| The two faces of mutation: extinction and adaptation in RNA viruses. | |
| | |
MedLine Citation:
|
PMID: 10772334 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
From a population standpoint, two main features characterize the replication of RNA viruses and viruses that use RNA as a replicative intermediate: high genetic variability, and enormous fluctuations in population size. Their genetic variability mainly reflects a lack of the proof-reading and post-replicative error correction mechanisms that operate during cellular DNA replication, but recombination and segment exchange can also play an important role. Viral population size can change tremendously as a consequence of transmission between hosts or between different tissues within an infected host. A new infection can be initiated with very few particles that subsequently expand many trillion-fold. Repeated bottleneck events can lead to drastic fitness losses or even to viral extinction, whereas continuously large population sizes result in fitness gains and adaptation. Here we review experimental evidence for the effects of mutation, selection, and genetic drift on the adaptation and extinction of RNA viruses. |
| | |
Authors:
|
S F Elena; R Miralles; J M Cuevas; P E Turner; A Moya |
Related Documents
:
|
8828154 - Molecular evolution of viruses: an interim summary. 19878744 - Diversity and evolution of chromatin proteins encoded by dna viruses. 9104494 - Hiv and human endogenous retroviruses: an hypothesis with therapeutic implications. 18625304 - Virus-like vesicles and extracellular dna produced by hyperthermophilic archaea of the ... 12589054 - Telomeric protein distributions and remodeling through the cell cycle in saccharomyces ... 12477244 - Detection of specific helicobacter pylori dna and antigens in stool samples in dyspepti... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review |
Journal Detail:
|
Title: IUBMB life Volume: 49 ISSN: 1521-6543 ISO Abbreviation: IUBMB Life Publication Date: 2000 Jan |
Date Detail:
|
Created Date: 2000-06-26 Completed Date: 2000-06-26 Revised Date: 2009-11-19 |
Medline Journal Info:
|
Nlm Unique ID: 100888706 Medline TA: IUBMB Life Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 5-9 Citation Subset: IM; S |
Affiliation:
|
Institut Cavanilles de Biodiversitat i Biología Evolutiva, Universitat de València, Spain. santiago.elena@uv.es |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adaptation, Physiological Evolution, Molecular Gene Frequency Models, Genetic Mutation* Point Mutation RNA Viruses / genetics* Recombination, Genetic Selection, Genetic Virus Replication |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Changes in the electrophoretic profiles of gill mucus proteases of the eastern oyster Crassostrea vi...
Next Document: Reactions of heme peroxidases with peroxynitrite.