Document Detail


The two faces of mutation: extinction and adaptation in RNA viruses.
MedLine Citation:
PMID:  10772334     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
From a population standpoint, two main features characterize the replication of RNA viruses and viruses that use RNA as a replicative intermediate: high genetic variability, and enormous fluctuations in population size. Their genetic variability mainly reflects a lack of the proof-reading and post-replicative error correction mechanisms that operate during cellular DNA replication, but recombination and segment exchange can also play an important role. Viral population size can change tremendously as a consequence of transmission between hosts or between different tissues within an infected host. A new infection can be initiated with very few particles that subsequently expand many trillion-fold. Repeated bottleneck events can lead to drastic fitness losses or even to viral extinction, whereas continuously large population sizes result in fitness gains and adaptation. Here we review experimental evidence for the effects of mutation, selection, and genetic drift on the adaptation and extinction of RNA viruses.
Authors:
S F Elena; R Miralles; J M Cuevas; P E Turner; A Moya
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  IUBMB life     Volume:  49     ISSN:  1521-6543     ISO Abbreviation:  IUBMB Life     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-06-26     Completed Date:  2000-06-26     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  100888706     Medline TA:  IUBMB Life     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  5-9     Citation Subset:  IM; S    
Affiliation:
Institut Cavanilles de Biodiversitat i Biología Evolutiva, Universitat de València, Spain. santiago.elena@uv.es
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological
Evolution, Molecular
Gene Frequency
Models, Genetic
Mutation*
Point Mutation
RNA Viruses / genetics*
Recombination, Genetic
Selection, Genetic
Virus Replication

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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