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A two-dimensional polarization interferometry based parallel scan angular surface plasmon resonance biosensor.
MedLine Citation:
PMID:  21361575     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
We describe a two-dimensional polarization interferometry based parallel scan angular surface plasmon resonance (SPR) biosensing technique. The method of line-shaped light illumination and parallel scan offers a high throughput. The simultaneous record of SPR angular spectrum enables the system to be unaffected by the time-dependent variation of the light source. The polarization interferometry technique lowers the minimum of the SPR dip and thereby reduces the noise related to the light intensity. Refractive index resolutions of 1.4 × 10(-6) refractive index unit (RIU) under normal condition and 4.6 × 10(-7) RIU under a more time-consuming condition are achieved in our angle interrogation based sensor. Meanwhile, a manually prepared DNA microarray has been detected, showing the potential applications of this technique in microarray analysis.
Authors:
Le Liu; Suihua Ma; Yanhong Ji; Xinyuan Chong; Zhiyi Liu; Yonghong He; Jihua Guo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Review of scientific instruments     Volume:  82     ISSN:  1089-7623     ISO Abbreviation:  Rev Sci Instrum     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-03-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0405571     Medline TA:  Rev Sci Instrum     Country:  United States    
Other Details:
Languages:  eng     Pagination:  023109     Citation Subset:  IM    
Affiliation:
Laboratory of Optical Imaging and Sensing, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, ChinaMOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, South China Normal University, Guangzhou 510631, China.
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