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A two-compartment toxicokinetic-toxicodynamic model to predict metal toxicity in Daphnia magna.
MedLine Citation:
PMID:  22871152     Owner:  NLM     Status:  Publisher    
Relating the toxicity of metals to their internal concentration is difficult due to the complicated detoxification processes within organisms. Only the metabolically available metals are potentially toxic to organisms, while metals in the detoxified form are toxicologically irrelevant. Accordingly, we developed a two-compartment toxicokinetic-toxicodynamic model for metals in a freshwater cladoceran Daphnia magna. The toxicokinetics simulated the whole bioaccumulation processes, while the toxicodynamics quantitatively described the corresponding processes of toxicity development. Model parameters were simulated for D. magna and three metals, i.e., cadmium, zinc and mercury, by fitting the literature data on metal bioaccumulation and toxicity. A range of crucial information for toxicity prediction can be readily derived from the model, including detoxification rate, no-effect concentration, threshold influx rate for toxicity, maximum duration without toxicity. This mechanistic model is flexible and can help for improving the ecological risk assessments for metals.
Q Tan; Wen-Xiong Wang
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-8
Journal Detail:
Title:  Environmental science & technology     Volume:  -     ISSN:  1520-5851     ISO Abbreviation:  Environ. Sci. Technol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0213155     Medline TA:  Environ Sci Technol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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