| The turnover of phospholipid fatty acyl chains is activated by the insecticide Dieldrin in Bufo arenarum oocytes. | |
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MedLine Citation:
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PMID: 10630421 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dieldrin is a widespread environmental contaminant hazardous to many wildlife species. Some evidence obtained with Bufo arenarum oocytes indicates that Dieldrin decreases the fertilization rate in amphibian oocytes, but little is known about mechanisms by which the pesticide affects fertilization. Therefore, we investigated the effect of Dieldrin on oocyte phospholipid metabolism. Freshly obtained oocytes, prelabeled with 2 3H-glycerol or 9-10 3H palmitate, were exposed to 4 mg/L Dieldrin for 2 hours. Dieldrin reduced the amount of 2 3H-glycerol incorporation in all phosphoglycerides classes: PI, PA, PS, and SPH were affected in 80% of the cases and PC and PE were only reduced in 39% of the cases. The incorporation in neutral lipids was not affected. On the contrary, 9,10 3H-palmitate incorporation increased in PC, PI, and PA, but TAG and FFA decreased. The more efficient incorporation of 3H-palmitate compared with 3H-glycerol in Dieldrin-treated oocytes suggests the operation of an alternative route other than de novo synthesis for phospholipids. The retailoring of phosphoglycerides via a deacylation-acylation pathway was demonstrated. These changes in phospholipid metabolism could be associated with the activation of certain enzymes produced by the pesticide. |
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Authors:
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T Fonovich de Schroeder; A M Pechen de D'Angelo |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of biochemical and molecular toxicology Volume: 14 ISSN: 1095-6670 ISO Abbreviation: J. Biochem. Mol. Toxicol. Publication Date: 2000 |
Date Detail:
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Created Date: 2000-01-24 Completed Date: 2000-01-24 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9717231 Medline TA: J Biochem Mol Toxicol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 82-7 Citation Subset: IM |
Affiliation:
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LIBIQUIMA, Facultad de Ingeniería, Universidad Nacional del Comahue, Buenos Aires, Neuquen, Argentina. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acylation Animals Bufo arenarum Dieldrin / toxicity* Fatty Acids / metabolism* Female Glycerol / metabolism Insecticides / toxicity* Oocytes / drug effects*, metabolism Palmitates / metabolism Phospholipids / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Insecticides; 0/Palmitates; 0/Phospholipids; 56-81-5/Glycerol; 60-57-1/Dieldrin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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