| A tumour cell aggregation promoting substance from rat ascites hepatoma cells. | |
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MedLine Citation:
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PMID: 4374963 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A substance capable of promoting tumour cell aggregation was released from rat ascites hepatoma cell (possibly from the cell surface) kept in Hanks' balanced salt solution (free of calcium and magnesium) in the cold, and then partially purified by chromatography with DEAE-Sephadex and gel filtration with Bio-gel. The thermostable substance seemed to be a glycoprotein and its molecular weight was about 72,000 when measured by gel filtration on Sephadex G-200. It had no proteolytic activity. The material was clearly effective for rat ascites hepatoma cells as well as SV40 transformed cells, but less effective for Chang's cells and apparently ineffective for normal rat liver cells and red blood cells. The action of this material was more potent than that of Jack bean concanavalin A when assayed for aggregation of SV40 transformed cells. Its effect was not influenced by concanavalin A inhibitors such as alpha-methyl-D-glucopyranoside, N-acetyl-D-glucosamine and D-glucose. |
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Authors:
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K Kudo; I Tasaki; Y Hanaoka; H Hayashi |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: British journal of cancer Volume: 30 ISSN: 0007-0920 ISO Abbreviation: Br. J. Cancer Publication Date: 1974 Dec |
Date Detail:
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Created Date: 1975-05-13 Completed Date: 1975-05-13 Revised Date: 2011-07-20 |
Medline Journal Info:
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Nlm Unique ID: 0370635 Medline TA: Br J Cancer Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 549-59 Citation Subset: IM |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carcinoma, Hepatocellular / analysis* Cell Aggregation / drug effects* Cell Separation Cell Transformation, Neoplastic Chromatography, Gel Concanavalin A / pharmacology Erythrocytes / drug effects Glucosamine / pharmacology Glucose / pharmacology Glycoproteins / antagonists & inhibitors, isolation & purification*, pharmacology Liver / drug effects Liver Neoplasms / analysis Male Methylglucosides / pharmacology Molecular Weight Rats Simian virus 40 Tissue Extracts / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Glycoproteins; 0/Methylglucosides; 0/Tissue Extracts; 11028-71-0/Concanavalin A; 3416-24-8/Glucosamine; 50-99-7/Glucose |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
| Full Text | |
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Journal Information Journal ID (nlm-ta): Br J Cancer ISSN: 0007-0920 ISSN: 1532-1827 |
Article Information Download PDF  Print publication date: Month: 12 Year: 1974 Volume: 30 Issue: 6 First Page: 549 Last Page: 559 ID: 2009342 PubMed Id: 4374963 PubMed Id: 4374963 |
| A Tumour Cell Aggregation Promoting Substance from Rat Ascites Hepatoma Cells* | |
| K. Kudo | |
| I. Tasaki | |
| Y. Hanaoka | |
| H. Hayashi | |
| *This is No. 1 of the studies on tumour cell aggregation promoting factor. |
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